Recurrent vulvovaginal candidiasis (RVVC) is a common illness influencing childbearing women worldwide. Most women suffering from RVVC develop infection without specified risk factors. Mannose-binding lectin (MBL) is an important component of innate immune defense against Candida infection. Innate immunity gene mutations and polymorphisms have been suggested to play a role in susceptibility to RVVC. This study aimed to investigate the association between MBL 2 gene exon 1 codon 54 polymorphism and susceptibility to RVVC in childbearing women. Whole blood and serum samples were obtained from 59 RVVC cases and 59 controls. MBL serum level was measured by enzyme-linked immune-sorbent assay (ELISA). MBL2 exon 1 codon 54 polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). It was shown that MBL serum level was nonsignificantly different between RVVC cases and controls. The risk of RVVC was 3 times higher in those carrying MBL2 exon 1 codon 54 variant allele (B). It could be concluded that the carrying of MBL2 exon 1 codon 54 variant allele (B) was shown to be a risk factor for RVVC in childbearing women.
Background: The causes of postmenopausal vaginal bleeding included endometrial atrophy, hyperplasia, polyps, submucosal myoma, and cancer. Every woman with postmenopausal bleeding (PMB) needs a meticulous clinical investigation since it has a 10 to 15 % of endometrial cancer. Objective: The aim of this work was to achieve an accurate evaluation of the uterine cavity in obese females with postmenopausal bleeding. Patient and Methods: A case-control study that was carried out over 6 months from March 2022 to August 2022 on 68 cases at Gynecology Outpatients in Obstetrics and Gynecology Department, Zagazig University Maternity Hospital where office hysteroscopy is performed. All patients were divided into two groups: Group A included 34 obese patients with post-menopausal uterine bleeding, while group B included 34 non-obese patients with post-menopausal uterine bleeding. All patients were subjected to full history taking, routine clinical examination, laboratory investigations and hysteroscopic evaluation. Results: There was no significant difference between the studied groups concerning the endometrial thickness, time, and amount of bleeding or histological sample distribution. They also revealed that endometrial polyps were significantly associated with non-obese group, but endometrial polyps + fibroids and proliferative endometrial hyperplasia were significantly associated with obese group. Conclusions: Obesity is a risk factor for the development of abnormal uterine bleeding in postmenopausal women considering its association with several uterine and endometrial pathologies causing postmenopausal bleeding.
Background: When used prior to a bowel injury, oral antibiotic bowel preparation (OABP) reduces intraluminal bacteria l load and, thus, the risk of surgical site infection (SSI). Objective: The aim of the current study was to investigate the role of preoperative oral antibiotic in gynecological oncology surgery in field visualization, reducing postoperative ileus and surgical site infection. Patients and methods: A cohort study was conducted on a total of 130 women who underwent tumor debulking surgery for gynecological cancer (ovarian, uterine, cervical or endometrial). On the day before surgery, patients received perioperative prophylactic oral antibiotics, and on the day of surgery, all patients were subjected to intravenous cephalosporin. Results: Preoperative oral antibiotic was associated with SSI incidence of 15.4%; 20 cases with surgical site infection (SSI) and 110 cases without SSI. Also favorable surgical field (reported as good or sufficient) was reported in 92.4% of cases. Return of intestinal function was early with mean duration of 19 hours. Conclusion: Preoperative oral antibiotic was associated with low incidence of SSI. Favorable operating field and early return of Bowel function.
Background: the polycystic ovary syndrome (PCOS) is important cause of an ovulatory infertility and a notable proportion of women of reproductive age are affected. Different factors could result in different manifestations and many of these are related to predispositions. Objectives: The study was carried out to study the improvement of ovulation induction in obese patients with Polycyctic ovarian syndrome (PCOS). Subjects and methods: This is prospective clinical trial that was conducted in the infertility unit of Zagazig university Hospital on 120 patient suffering from PCOS were included in this study during the period from Actober 2018 to May 2019. This trial was designed to compare the improving induction of ovulation in obese females with Polycystic ovarian syndrome undergoing induction of ovulation by Clomid and Metformin (n=60) or Letrozole (n=60).Results: There was no significant statistical difference between Clomid and Metformin group and letrozole group in term of pregnancy rate, There was a significant statistical difference between Clomid and Metformin group and letrozole group in term of Size of dominant Graafian follicle (on day 11) (p=0.03) and the Size of dominant Graafian follicle (on day 13-14) (p=0.01).Conclusion Letrozole improves endometrial thickness and cervical mucosa and causes monofollicular ovulation but action of clomiphene citrate combined with metformin improved the ovulation and increased total number of follicles. Therefore, Letrozole can be used for the ovulation induction improvement in obese women having PCO
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