Background: Cardiopulmonary resuscitation is the emergency procedure used to salvage victims of cardiac and respiratory arrest. It should be carried out with great urgency to avoid permanent brain damage or even death that would result if the victim stays from 4 to 6 minutes without oxygen. The aim of study: To assess the effectiveness of structured teaching program on the skills of cardio pulmonary resuscitation among the nursing staff in the Khartoum Teaching, Ahmed Gasim, Omdurman Teaching, and the Khartoum North Teaching hospitals. Methods: A quasi experimental design pretest/posttest for the same group. The study was conducted in the intensive care units in Khartoum hospitals. The study sample consisted of 100 nurses. Data was collected by a questionnaire and an observational checklist. The intervention program was in a form of lectures guidelines book. Data were analyzed using Statistical Packages for Social Sciences (SPSS). Results: the study showed the Nurses' skills before implementation program poor (57%) good (31%) very good (12%). Nurses' skills after implementation program poor (4%) good (18%) very good (78%), (P value 0.002). Conclusion: The study concluded that educational program had a significant impact related to the improvement of the nurses' practice post application of the program. Key words: Training program, Practice, Nurses, Intensive Care Unit.

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