The analogs of nitrogen-based heterocycles occupy an exclusive position as a value of more than 75%
of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic
moieties. Among many N-containing heterocycles, quinolines have become important due to their
variety of applications in medicinal, synthetic organic chemistry as well as in the field of industrial
chemistry. Present work gives information about the green and clean synthesis using multicomponent
reactions (MCRs) methods and L-proline and ammonium acetate as a catalyst for the synthesis of
quinoline derivatives. Synthesized quinoline derivatives undergo spectroscopic analysis and their
biological evaluation.
In current times, researchers adopted the click chemistry approach for the synthesis of various druglike
molecules by using a few reliable, feasible, practical and selective chemical transformations via
click formation. In present work, we focussed on the most triazole clubbed thiazolidine-2,4-dione
derivatives as the most promising motifs for broad biological application. A total of fifteen (CF-4a-o)
derivatives were synthesized and well characterized with various analytical techniques.
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