Cognitive disturbances after traumatic brain injury (TBI) are frequent, even when neuroimaging shows no overt hemorrhagic or other abnormality. Sulfonylurea receptor 1 (SUR1) plays a key role in various forms of CNS injury, but its role in hippocampal dysfunction after mild to moderate TBI is unknown. To assess the hypothesis that postinjury SUR1 upregulation in the hippocampus is associated with a later disturbance in learning, we studied a rat model of cortical impact TBI calibrated to avoid primary and secondary hemorrhage in the underlying hippocampus. The transcription factor, specificity protein 1, which regulates expression of SUR1 and caspase-3, was activated in the hippocampus 15 minutes after injury. Upregulation of SUR1 protein and of Abcc8 (which encodes SUR1) messenger RNA was evident by 6 hours. To assess the role of SUR1, injured rats were administered vehicle or a low dose of the specific sulfonylurea inhibitor glibenclamide for 1 week. At 2 weeks, the increase in activated caspase-3 in the hilus of glibenclamide-treated rats was half of that in vehicle-treated rats. Testing for rapid learning in a Morris water maze at 4 weeks showed significantly better performance in glibenclamide-treated rats; performance inversely correlated with Fluoro-Jade staining for degenerated neurons in the hilus. We conclude that glibenclamide may have long-term protective effects on the hippocampus after mild-to-moderate TBI.

Sustainable use of groundwater is becoming critical in India and requires effective participation from local communities along with technical, social, economic, policy and political inputs. Access to groundwater for farming communities is also an emotional and complex issue as their livelihood and survival depends on it. In this article, we report on transdisciplinary approaches to understanding the issues, challenges and options for improving sustainability of groundwater use in States of Gujarat and Rajasthan, India. In this project, called Managed Aquifer Recharge through Village level Intervention (MARVI), the research is focused on developing a suitable participatory approach and methodology with associated tools that will assist in improving supply and demand management of groundwater. The study was conducted in the Meghraj watershed in Aravalli district, Gujarat, and the Dharta watershed in Udaipur district, Rajasthan, India. The study involved the collection of hydrologic, agronomic and socio-economic data and engagement of local village and school communities through their role in groundwater monitoring, field trials, photovoice activities and education campaigns. The study revealed that availability of relevant and reliable data related to the various aspects of groundwater and developing trust and support between local communities, NGOs and government agencies are the key to moving towards a dialogue to decide on what to do to achieve sustainable use of groundwater. The analysis of long-term water table data indicated considerable fluctuation in groundwater levels from year to year or a net lowering of the water table, but the levels tend to recover during wet years. This provides hope that by improving management of recharge structures and groundwater pumping, we can assist in stabilizing the local water table. Our interventions through Bhujal Jankaars (BJs), (a Hindi word meaning "groundwater informed" volunteers), schools, photovoice workshops and newsletters have resulted in dialogue within the communities about the seriousness of the groundwater issue and ways to explore options for situation improvement. The BJs are now trained to understand how local recharge and discharge patterns are influenced by local rainfall patterns and pumping patterns and they are now becoming local champions of groundwater and an important link between farmers and project team. This study has further strengthened the belief that traditional research approaches to improve the groundwater situation are unlikely to be suitable for complex groundwater issues in the study areas. The experience from the study indicates that a transdisciplinary approach is likely to be more effective in enabling farmers, other village community members and NGOs to work together with researchers and government agencies to understand the groundwater situation and design interventions that are holistic and have wider ownership. Also, such an approach is expected to deliver longer-term sustainability of groundwater at a regional level.

BackgroundLittle is known about the prognostic implications of frailty, a state of susceptibility to stressors and poor recovery to homeostasis in older people, after myocardial infarction (MI).Methods and ResultsWe studied 3944 MI patients aged ≥65 years treated at 41 Australian hospitals from 2009 to 2016 in the CONCORDANCE (Australian Cooperative National Registry of Acute Coronary Care, Guideline Adherence and Clinical Events) registry. Frailty index (FI) was determined using the health deficit accumulation method. All‐cause and cardiac‐specific mortality at 6 months were compared between frail (FI >0.25) and nonfrail (FI ≤0.25) patients. Among 1275 patients with ST‐segment–elevation MI (STEMI), 192 (15%) were frail, and among 2669 non‐STEMI (NSTEMI) patients, 902 (34%) were frail. Compared with nonfrail counterparts, frail STEMI patients received 30% less reperfusion therapy and 22% less revascularization during index hospitalization; frail NSTEMI patients received 30% less diagnostic angiography and 39% less revascularization. Unadjusted 6‐month all‐cause mortality (STEMI: 13% versus 3%; NSTEMI: 13% versus 4%) and cardiac‐specific mortality (STEMI: 6% versus 1.4%, NSTEMI: 3.2% versus 1.2%) were higher among frail patients. After adjustment for known prognosticators, FI was significantly associated with higher 6‐month all‐cause (STEMI: odds ratio: 1.74 per 0.1 FI [95% confidence interval, 1.37–2.22], P<0.001; NSTEMI: odds ratio: 1.62 per 0.1 FI [95% confidence interval, 1.40–1.87], P<0.001) but not cardiac‐specific mortality (STEMI: P=0.99; NSTEMI: P=0.93).ConclusionsFrail patients receive lower rates of invasive cardiac care during MI hospitalization. Increased frailty was independently associated with increased postdischarge all‐cause mortality but not cardiac‐specific mortality. These findings inform identification of frailty during MI hospitalization as a potential opportunity to address competing risks for mortality in this high‐risk population.

No abstract

No abstract

Dietary calcium intake modifies the relationship between serum 25OHD concentrations and intact serum PTH concentrations. Thus, dietary calcium intake should be taken into account when assessing an individual's vitamin D status.

The production of clean metal, free from oxides and other types of nonmetallic inclusions, is central to product quality and performance. Toward this end, electromagnetic filtration is an emerging technology for the purification of molten metals. This paper reviews the theory and the mechanism of the electromagnetic separation of incl usions from molten metal and describes the induced-current electromagnetic separator developed at the University of Alabama. The results of laboratory and large-scale experiments on the purification of molten aluminum demonstrate the capability of the system for producing superclean metals. Figure 1 . A schematic ofthe separation chamber of the induced-current separator.46

No abstract