Hepatoprotective activity of stem bark extracts of Ficus religiosa Linn. (Moraceae) investigated against Paracetamol (2g/kg) induced hepatotoxicity in rats. Stem bark powder of Ficus religiosa was successively extracted with different solvent by soxhlet apparatus. The extracts of F. religiosa stem bark were administered in a dose of 200 mg/kg orally. Silymarin (100mg/kg) was used as standard drug. The hepatoprotective effect of these extracts was evaluated by the assessment of biochemical parameter such as SGOT, SGPT, ALP, Total bilirubin, and histopathological studies of the liver. The preliminary Phytochemical screening of F. religiosa revealed the presence of Triterpenoids, Flavonoids, Saponins, Steroids, Tannins and Phenolic compounds, Carbohydrate, Protein. The treatment with extract of F. religiosa showed significant reduction of Paracetamol induced elevated serum enzyme levels. The present study shows that extract of Ficus religiosa L. has significant hepatoprotective activity and methanolic extract was found to exhibit greater hepatoprotective activity than the other extract.
Objective: To investigate the effect of traditional cannabis preparation (TCP) on paracetamol induced hepatic injury in rats. Methods: Wistar rats weighing between 150-200 gm and each group contains 6 animals.Test group of animals were treated with paracetamol (2gm/kg bw po).Silymarin (100mg/kg bw po) was used as a standard reference. TCP (0.5ml/100gm po) was given alone and to the group intoxicated with paracetamol. Thereafter, the activities of alanine aminotransferase (ALT), aspartate amino transferase (AST) and alkaline phosphatase (ALP) were assayed in the serum. The levels of other biochemical markers of organ damage such as total bilirubin, pentobarbitone induced sleeping time, liver weight and liver volume were also determined. Histological examination of the liver was performed. Result: Group of rats received TCP showed relatively lower increase in liver enzyme parameters as compared with group of rats treated with PCM alone. However, these values were elevated when compared to normal, untreated group of rats. Also, group of rats received TCP followed by PCM showed significant increase in liver ezyme parameters as compared to PCM alone treated group of rats. However, these values were approximately 2 times higher as compared to normal, untreated group of rats. Conclusion: In the present study, toxic nature of TCP was dependent on the pathological state of liver as its consumption in diseased condition were further enhancing the pathologies of liver which was revealed through elevated levels of various biochemical marker, when oral feeding of TCP in paracetamol intoxicated rat.
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