No abstract

We observed preliminary signs of in vivo reversal of RAI resistance after treatment with romidepsin. However, no major responses were observed and accrual was poor after the grade 5 AE.

Background: Neo-adjuvant chemotherapy is an integral part of multi-modality approach in the management of locally advanced breast cancer and it is vital to predict the response in order to tailor the regime for a patient. The common final pathway in the tumor cell death is believed to be apoptosis or programmed cell death and chemotherapeutic drugs like other DNA-damaging agents act on rapidly multiplying cells including both the tumor and the normal cells by following the same common final pathway. This could account for both the toxic effects and the response. Absence or decreased apoptosis has been found to be associated with chemo resistance. The change in expression of apoptotic markers (Bcl-2 and Bax proteins) brought about by various chemotherapeutic regimens is being used to identify drug resistance in the tumor cells. A prospective clinical study was conducted to assess whether chemotherapy induced toxic effects could serve as reliable predictors of apoptosis or response to neo-adjuvant chemotherapy in patients with locally advanced breast cancer.

Fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is increasingly used in the initial staging, evaluation of treatment response, and surveillance of many malignancies. Uptake of FDG is substantially increased in most malignancies, compared with its uptake in normal tissues, and the finding of FDG avidity often leads to cancer detection earlier than abnormalities can be seen at anatomic imaging. However, FDG is not a cancer-specific agent, and FDG avidity can be seen in many benign processes. It can be particularly challenging to discriminate malignancy from benign FDG-avid changes caused by surgery and procedures, radiation therapy, and chemotherapy. FDG-avid abnormalities caused by surgery and procedures include inflammation at sites of incision or dissection, inflammation from vascular compromise or surgical retraction, surgical transposition of structures with physiologic FDG avidity (such as ovaries or testes), and pleurodesis inflammation. Radiation therapy may induce FDG-avid pneumonitis, esophagitis, or hepatitis, as well as osteoradionecrosis or fractures. FDG-avid chemotherapy complications include pneumonitis, osteonecrosis, enterocolitis, and pancreatitis. Use of granulocyte colony stimulating factor for treatment of bone marrow suppression after chemotherapy induces temporary increases of FDG avidity in the bone marrow and spleen. Familiarity with common and unusual iatrogenic causes of FDG avidity that can confound interpretation of FDG PET/CT results will improve the accuracy of distinguishing treatment effects and complications from residual or recurrent malignancy at FDG PET/CT examinations.

A 52-year-old woman with metastatic melanoma was treated with ipilimumab. After 2 cycles of treatment, she developed watery diarrhea, sweats, and chills. An FDG PET/CT study demonstrated new FDG-avid (maximum standardized uptake value 15.6) diffuse colonic wall thickening, suggestive of ipilimumab-induced colitis. The patient was treated with systemic steroids, with subsequent resolution of her symptoms. Based on the response to steroids, the diagnosis of ipilimumab-induced enterocolitis was made. Ipilimumab may cause several immune-mediated toxicities, the most common of which is enterocolitis. Physicians interpreting FDG PET/CT examinations of patients treated with ipilimumab should be aware of these FDG-avid immune-mediated toxicities.

We report the effects of treadmill exercise on 18 F-FDG uptake in skeletal muscles and image quality of torso PET and compare stress myocardial perfusion imaging patterns with myocardial 18 F-FDG uptake. There were 3 groups of patients: 48 patients underwent PET within 8 h after a treadmill test (Ex 8), 45 patients within 48 h after a treadmill test (Ex 48), and 34 patients without prior exercise. Mean workload (8.4 6 2.3 [Ex 8] vs. 8.9 6 2.6 metabolic equivalents [Ex 48]) was similar in both exercise groups. Muscle uptake was assessed by standardized uptake value. Myocardial uptake patterns were compared visually. Minor differences between patient groups were noted only for maximum standardized uptake value in quadriceps muscles. There was no correlation between perfusion defects and myocardial 18 F-FDG uptake patterns. Thus, treadmill exercise does not affect muscle 18 F-FDG uptake or image quality on subsequent PET. Cardiac 18 F-FDG uptake on torso PET scans is unrelated to myocardial perfusion status.

A 70-year-old man underwent partial gastrectomy with pathology demonstrating gastric follicular lymphoma. After surgery, a staging FDG PET/CT study demonstrated an FDG-avid low-attenuation band in the liver. Corresponding MRI demonstrated a high T2 signal abnormality. This was believed to represent liver parenchymal injury due to liver retraction during surgery. The patient was managed conservatively. MRI at 1 month of follow-up demonstrated resolution of the T2 signal abnormality. FDG PET/CT at 6 months of follow-up demonstrated resolution of FDG uptake. Tissue injury from surgical retraction can produce FDG-avid lesions that need to be distinguished from malignancy on PET/CT.

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