Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells lining the nasopharynx. The development of a second primary tumor in subjects with a previous history of nasopharyngeal carcinoma is a rare event. The most common second primary cancer which can occur is sarcoma (0.14%), followed by leukemia and squamous cell carcinoma. In the present case, a second primary tumor (squamous cell carcinoma) on right lateral border of tongue in a 64 year old male patient treated for nasopharyngeal carcinoma with radiotherapy and chemotherapy 5 years previously is discussed. …………………………………………………………………………………………………….... Introduction:-Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells lining the nasopharynx. 1 The development of a second primary malignant tumor in subjects with a previous history of nasopharyngeal carcinoma is unusual. 2 The most common second primary cancer which can occur is sarcoma (0.14%), followed by leukemia and squamous cell carcinoma. 2 These second primaries can occur in the lung, oesophagus and also in the head and neck region. 2 In the oro-pharyngeal region, tongue is a common site of involvement (1.8%). 2 The proposed pathogenic mechanisms of the development of second primary cancers include radiotherapy, field cancerization and common risk factors. 2 The present case is of second primary tumor (squamous cell carcinoma) on right lateral border of tongue in a 64 year old male patient treated for nasopharyngeal carcinoma.Case Report:-A 64 year old male visited the department of Oral medicine and Radiology with a complaint of frequent biting of the right side of the tongue while eating and talking since 6 months. He had visited several dental practitioners for the management of the same and coronoplasty of maxillary and mandibular posterior teeth was performed. However, there was no relief. He had visited an oncology centre 2 days prior to visiting the present institution for a PET-CT scan. The scan was advised as a part of the follow-up protocol for treated nasopharyngeal carcinoma that was diagnosed 5 years ago. Patient had undergone radiotherapy and chemotherapy for the same. The treatment was completed 4 years ago. An increased FDG uptake was noted on PET-CT with regard to the right lateral aspect of tongue.He was advised partial glossectomy by the oncosurgeon for the same.
Background and objectives:Obese subjects have an inherent chemosensory deficit due to reduced Fungiform papillae density (FPD) resulting in increased food consumption. The study aimed to assess the relationship between Body mass index (BMI) and Fungiform papillae density in subjects with increased and normal BMI. Methodology: A total of 110 subjects were randomly included in the study. The BMI of the subjects was calculated after recording the height and weight of the subjects. Subjects were categorized as Normal weight (18.0 to 22.9 kg/m 2 ), Overweight (23.0 to 24.9 kg/m 2 ) and Obese (Greater than 25 kg/m 2 )based on the standard BMI definition values of Asian Indian population. The FPD was assessed on a photograph of a stained area of the tongue. Scoring of fungiform papillae was done using the Denver Papillae Protocol Dichotomous Key and counted using a software.Results were tabulated and statistically analyzed. Results: There was a significant negative correlation between BMI and FPD (correlation= -0.344, p=0.000) among the normal weight, overweight and obese subjects. Multiple regression analysis revealed a significant reduction in FPD with increasing frequency of eating sweets and fatty foods (p=0.028 and 0.023 respectively). Conclusion: A reduction in FPD was noted with increase in BMI which in turn may have a role in food consumption pattern of an individual.
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