Introduction: "Chemotherapy Spill Kit (CSK)" is a kit with various configurations and contents designed for safe and fast clean-up of chemotherapy drug spills in accordance with standard guidelines. Thus, nurses can minimize exposure to hazardous drugs with the use of personal protective equipment and careful technique with the use of this kit. Hence, these spill kits should be available wherever chemotherapy is located.Objectives: The objectives of the study were to develop a CSK and validate the kit and assess the acceptability of CSK among the nurses in oncology wards of the selected hospital. Methodology:The conceptual framework of the present study was based on integrating models of diffusion of innovations, which was first proposed by Barbara Wejnert, which consists of characteristics of innovations, characteristics of innovators, and environmental characteristics. Quantitative research approach and methodological research design was used. Tools used for data collection comprised of rating scale criteria to validate the items of CSK by 11 experts from the field of medical-surgical nursing and oncology and to assess the acceptability of CSK among nurses. Non-probability purposive sampling was adopted to select the sample. The study was conducted on 60 nurses working in oncology wards of Safdarjung Hospital, New Delhi. Result:The data collected was analyzed using descriptive statistics. Content Validity Index (CVI) was used to validate items of CSK. Following validation by the experts, the acceptability of the CSK was assessed. The major findings of the study showed a very positive validation by all the experts with mean CVI score of 0.98, median 1.00, mode of 1.00 and standard deviation of 0.11772. CVI score of more than 0.78 was considered to be valid for this study. From an acceptability perspective, 100% of the subjects found CSK to be highly acceptable. Conclusion:The conclusion drawn from the study was a positive validation of CSK by 11 experts and an overwhelming acceptability of the CSK. Further all the study subjects opined for the need of CSK in oncology
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