Background: Despite the advances in treating burn injuries, burn severity remains one of the most challenging cases to be treated. As technologies advances, regenerative therapies using stem cells have been established and found to be effective and friendly as a regenerative tool. Stromal vascular fraction (SVF), extracted from adipose tissue, has a great potential for multipotent mesenchymal stem cells differentiation. Recent research has determined the therapeutic effects of SVF on burn injury. Previous finding has proved the efficacy of using SVF that is isolated enzymatically. This research aimed to examine the efficacy of allogenic mechanically isolated (MI) SVF in treating deep partial-thickness burns in a Wistar rat. Materials and Methods: After burn induction, 45 rats were divided into three groups of 15 as follows: group one (control, treated with phosphate-buffered saline), group two (treated with silver sulfadiazine (SSD), and group three (injected with SVF). SVF was harvested from the inguinal fat pad of six rats and mechanically processed. All injections were administered intradermally at the four edges of the burn to cover the entire wound bed. Morphological and histopathological analyses were performed for all groups at three different time points (4, 8, and 32 d post-treatment). Results: Treatment with MI SVF significantly reduced edema formation and dryness of the wound bed on day one compared to the control (P = 0.001). Histopathological results showed that SVF significantly reduced inflammation compared to the control (P = 0.045) on day one and increased neovascularization on day 8 (P = 0.016). Epithelial thickness was significantly greater in the SVF group compared to the SSD group (P = 0.034). Conclusions: The results of this study indicated the therapeutic potential of MI SVF on deep-partial-thickness burns by increasing neovascularization and epithelial thickness and reducing inflammation.
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BACKGROUND The significance of radiological assessment in the treatment plan of patients with adenoid hypertrophy cannot be undermined. This study evaluated the correlation between clinical symptoms and radiological findings in the clinical assessment of patients with adenoid hypertrophy. METHODS A cross-sectional study was conducted by recruiting 147 individuals aged between 1 to 27 years from September 2017 to February 2018. Clinical assessment was performed through questionnaires prepared for primary caregivers. Radiographic findings were obtained through lateral nasopharyngeal radiographs. Frequencies, percentages, cross-tabulation, chi-square analysis, and Pearson correlation test were used to analyse the collected data via Statistical Package for Social Sciences (SPSS). RESULTS A positive correlation was observed between clinical presentations of snoring and adenoid thickness. No significant correlations were observed between mouth breathing, obstructive breathing during sleep, and the total clinical score obtained with the nasopharyngeal diameter. A significant correlation of nasopharyngeal diameter with mouth breathing and soft palate thickness was noted. The ratio of soft-palate tissue was also significantly correlated with nasopharyngeal diameter. CONCLUSIONS Findings revealed a significant correlation between mouth breathing with all the radiological findings at 5% level of significance. It also suggests that suspected adenoid hypertrophy in children can be treated with lateral radiograph of the nasopharynx for better treatment outcomes.
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