Objective: The objective of this study was to evaluate the effect of intravenous fluid supplementation in healthy term neonates with non-hemolytic hyperbilirubinemia receiving phototherapy. Study Design: Randomized controlled trial conducted in a tertiary level neonatal care unit of a teaching institute in North Karnataka. Methods: A total of 60 healthy term neonates with non-hemolytic hyperbilirubinemia (total serum bilirubin [TSB] >15 mg/dL [256 ?mol/L]–<25 mg/dL [428 ?mol/L]) were randomized to two groups. Group I (case group, n=30) received 1/3rd the maintenance intravenous fluid in addition to breastfeeding and phototherapy. Group II (control group, n=30) received only breastfeeding and phototherapy. The duration of phototherapy and rate of fall of bilirubin was compared. Results: Both the groups were comparable with respect to mean birth weight, gestational age, gender, mode of delivery, age at admission, admission weight, percentage of weight loss at admission, and TSB at inclusion. There was a significant difference in the duration of phototherapy between the two groups (mean [standard deviation (SD)] Group I, 39.6 [7.8] h and Group II, 45.2 [10.22] h, p<0.05). Percentage of fall in bilirubin was not significant at 4, 12, 48, and 60 h but was significant at 24 and 36 h. Conclusion: Intravenous fluid supplementation in healthy breastfed term neonates with non-hemolytichyperbilirubinemia significantly reduces the duration of phototherapy.
Objective: To study whether vitamin D supplementation in children presenting with pneumonia and severe pneumonia reduce its duration of recovery. Study design: Randomized, Double blind, Placebo-controlled trial. Setting: Paediatric unit of a Teaching hospital. Methods: 80 children between 2 months-5 years with diagnosis of pneumonia and severe pneumonia (as per the WHO definition) admitted over a period of one year were included. Children with features of rickets, severe malnutrition, history of asthma, any underlying medical disorders and vitamin D supplementation over the last 12 months were excluded. Children were randomized to two groups, Intervention group received 300,000 IU of Vitamin D (1ml) and the control group received 1ml of Sterile water as a placebo intra muscularly along with antibiotics and supportive care. Children were monitored for the resolution of symptoms. The two groups were comparable for baseline demographic, socioeconomic, clinical and laboratory parameters. Results: There was no significant difference in time to resolution of symptoms (fever, tachypnea and chest retractions) in Intervention group (3.63±1.27 days) & placebo group (3.6±0.78 days), p=0.933). Conclusion: Supplementation of single high dose (300,000 IU) of vitamin D given intramuscularly have no beneficial effect on the resolution of pneumonia and severe pneumonia in the children of 2months to 5years of age.
Objective: To find the MUAC cut-off for detection of severe acute malnutrition in infants between 1to 6 months of age. Material and Methods: A prospective observational study at IPD and OPD of atertiary care hospital. 303 infants between one and six months of age above the length of 45cmswere included in the study. In infants between one and six months of age, the length, weight, andMUAC were measured. SAM infants were identified using the WHO definition. Sensitivity, specificity,and Youden index for a particular MUAC was calculated in SAM infants. Results: 11cms was found tohave a sensitivity of 85.1% and specificity of 65.9%. It had the maximum Youden index of 0.55 witha positive likelihood ratio of 2.79 and a negative likelihood ratio of 0.21. Conclusions: MUAC of11cms can be used as a cut-off for SAM infants between 1 to 6 months of age. MUAC does not varywith gender. Weight and MUAC are significantly lower in SAM infants. But there is no difference whenit comes to length as in acute malnutrition, the weight and MUAC are affected but length is not.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.