The DAH proton source assisted Fe2O3–TiO2 system exhibits exceptional photocatalytic activity and stability for hydrogen generation by a water-splitting reaction.
Nanoparticle-mediated starvation
therapy is a promising
therapeutic
approach for cancer treatment. Here, we report a novel therapeutic
nanosystem (GOx@PEG-MnFe2O4) composed of glucose
oxidase (GOx) loaded in polyethylene glycol (PEG) modified manganese
ferrite (MnFe2O4) nanoparticles (NPs) for cancer
starvation therapy. GOx catalyzes the oxidation of glucose to gluconic
acid and hydrogen peroxide (H2O2) by consuming
oxygen (O2) in an acidic environment. Meanwhile, NPs can
catalyze the oxidation of H2O2 to generate O2, which, in turn, aids in the depletion of glucose and eliminate
the hypoxia condition. Phase identification, crystal structure, and
size of the NPs confirm the cubic spinel structure with an average
crystallite size of 21 nm. NPs exhibit good magnetic susceptibility
with a magnetization value of ∼75 emu/g at room temperature.
Heating potentiality of the NPs with an obtained specific absorption
rate (SAR) of 296 W/g proves the efficacy of NPs to act as a heating
agent for cancer hyperthermia, which aid for a synergistic therapy
combining magnetic hyperthermia with glucose oxidase-based starvation
therapy. Fourier transform infrared spectroscopy and thermogravimetry
analysis confirm the successful loading of GOx onto the PEG-MnFe2O4 nanosystem. The nanosystem exhibited ∼82%
release of GOx in the cancer cell-mimicking environment in an applied
magnetic field which is around 1.8 times higher than that in the normal
cell-mimicking environment. In vitro assessment against
HeLa and Saos-2 cancer cell lines demonstrated anticancer activity
and exhibited reduced hemolysis rates. Furthermore, the in
vitro results suggested that the NPs are biocompatible and
have potential hyperthermic ability. The designed nanosystem is capable
of effectuating the tumoricidal effect via cancer starvation therapy.
Antibacterial activity of nanoparticles (NPs) and nanocomposites (NCs) has received wide spread attention in biomedical applications. In this direction, the authors prepared zinc oxide (ZnO), iron oxide (Fe 3 O 4), and their composite including reduced graphene oxide (rGO) by hydrothermal method. The structural and microstructural properties of the synthesised NPs and NCs were investigated by XRD, FT-IR, UV-Vis, TGA, and TEM analysis. PEG-coated ZnO and Fe 3 O 4 form in hexagonal wurtzite and inverse spinel structures, respectively. ZnO forms in rod-shaped (aspect ratio of ∼3) morphology, whereas well-dispersed spherical-shaped morphology of ∼10 nm is observed in Fe 3 O 4 NPs. The ZnO/Fe 3 O 4 composite possesses a homogeneous distribution of above two phases and shows a very good colloidal stability in aqueous solvent. These synthesised particles exhibited varying antibacterial activity against gram-positive strain Staphylococcus aureus (S. aureus) and gram-negative strain Escherichia coli (E. coli). The nanocomposite exhibits a better cidal effect on E. coli when compared to S. aureus when treated with 1 mg/ml concentration. Further, the addition of rGO has intensified the anti-bacterial effect to a much higher extent due to synergistic influence of individual components.
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