Functionalization and derivatization of arylhydrazones
are important
in pharmaceutical, medicinal, material, and coordination chemistry.
In this regard, a facile I2/DMSO-promoted cross-dehydrogenative
coupling (CDC) for direct sulfenylation and selenylation of arylhydrazones
has been accomplished utilizing arylthiols/arylselenols at 80 °C.
This method provides a metal-free benign route for the synthesis of
a variety of arylhydrazones embedded with diverse diaryl sulfide and
selenide moieties in good to excellent yield. In this reaction, molecular
I2 acts as a catalyst, and DMSO is utilized as a mild oxidant
as well as solvent to produce several sulfenyl and selenyl arylhydrazones
through a CDC-mediated catalytic cycle.
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