ABSTRAK Pengobatan tradisional di Indonesia sudah di kenal masyarakat jauh sebelum pelayanan kesehatan formal dengan obat-obatan modern. Indonesia memiliki banyak spesies tanaman yang
Strobilanthes crispus plants are very potential as natural antidiarrheal drugs because of their phytochemical content, namely tannins, silicates, and catechins which are natural compounds of the flavonoid group. This study aimed to determine the potential of Strobilanthes crispus extract as an anti-diarrhea drug. The target of this study was to test the potential of ethanol extract of the leaves of Strobilanthes crispus as antidiarrheal. This study used the experimental laboratory method. The research stages included the selection of herbal ingredients, manufacturing of simplicia, ethanol extraction of Strobilanthes crispus using remaceration method, and testing the potential of ethanol extract of the leaves of Strobilanthes crispus against Escherichia coli and Streptococcus mutans using a good diffusion method with three replications each, measuring the diameter of the inhibition zone. The measurement results of inhibitory zone diameters of Strobilanthes crispus extract against Escherichia coli and Streptococcus mutans bacteria at concentrations of 15%, 30%, 45%, 60%, 75% each were 0 mm and at 100% concentration, the average was 16.33 mm for Escherichia coli and 17 mm for Streptococcus mutans. Based on the diameter of the inhibition zone showed MIC to Escherichia coli and Streptococcus mutans at a concentration of 100%. Strobilanthes crispus extract is more effective for diarrhea caused by Streptococcus mutans than Escherichia coli.
Background: COVID-19 has become a health problem in the world, including in Indonesia. The high number of COVID-19 transmissions in Indonesia shows the need for massive prevention efforts. In addition to vaccination, the 5M health protocol is an effective way to reduce the number of COVID-19 transmissions. The implementation of the 5M program is influenced by several factors, including knowledge about COVID-19 and history of comorbidities.Methods: This study is an observational-analytic study that aims to analyze the influence of comorbid history during last 3 months and knowledge aobut COVID-19 disease on 5M practice in the Madiun community. 5M practices in this research include wearing masks, washing hands, maintaining distance, avoiding crowds and maintaining immunity. The research design used in this study was cross sectional with the sampling technique used was purposive sampling. Data was obtained by distributing online questionnaires to people living in the Madiun area. The population in this study is the people of Madiun, and the sample in this study is the people of Madiun who voluntarily fill out online questionnaire. The study was carried out for 7 months, starting from June to December 2020.Result: From the results of the Chi square test, it was concluded that the comorbid history and the knowledge about COVID-19 have an effect on 5M practice (comorbid history p = 0.001 and knowledge about COVID-19 p = 0.000).Conclusion : The results of this study are expected to be an input for the government in determining policies to prevent COVID-19, especially in the Madiun area.
Poor sanitation and environmental hygiene are factors that cause the high incidence of diarrhea in Indonesian children. The use of traditional medicines derived from plants is increasingly in demand by the public. The Strobilanthes crispus plant is very potential as a natural antidiarrheal drug because of its phytochemical content, namely tannins, silicates, and catechins which are natural compounds of the flavonoid group. The purpose of this study was to determine the effectiveness of Strobilanthes crispus extract as an antidiarrheal. This study uses an experimental laboratory method. Group I. 100 mg/Kg BW, group II. 200 mg/Kg BW, group III. 400 mg/Kg BW, group IV. 800 mg/Kg BW, group V. positive control (+) loperamide 2 mg, and group VI. negative control (-) distilled water. Induction of diarrhea with castor oil. The results of the positive control statistical test with the negative control showed that the p value <0.05 was significant, there was a difference in the time of diarrhea in mice that were given loperamide and mice that were not given loperamide. The results of the statistical test of negative control and the treatment of giving kejibeling extract showed that the p value <0.05 there was a difference in the time of diarrhea in mice that were given kejibeling extract and those that were not given kejibeling extract. The results of statistical tests on the treatment of Kejibeling extract with positive control showed that the p value> 0.05 had no effect on the time of diarrhea. This indicated that the kejibeling extract had the same effect as the positive control (loperamide). Kejibeling can be used as an alternative to loperamide.
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