Цель исследования-изучить влияние имплантации в большеберцовую кость гидроксилапатита и перорального введения препаратов кальция на прочностные характеристики плечевых костей крыс. Эксперимент поставлен на 210 самцах лабораторных крыс, имеющих исходную массу тела от 135 до 145 г: А-группа-контроль, в Б-группе перфорировали большеберцовые кости, в В-группе производили пластику дефекта материалом ОК-015. В Г-группе после перфорации и в Д-группе после имплантации применяли «Биомин МК» внутрижелудочно через зонд из расчета 90 мг/кг/сутки. Прочность плечевых костей исследовали при изгибе с трехточечной моделью нагружения. Перфорация большеберцовых костей приводила к падению прочности плечевых костей с максимальными отклонениями к 30-м суткам после операции. Имплантирование материала ОК-015 в ранние сроки после операции сопровождалось усугублением выявленных отклонений, с 30-х суток восстановление прочности происходит быстрее. При внутрижелудочном зондовом введении препарата «Биомин МК» после перфорации большеберцовых костей величина минимальной работы разрушения превышала показатели Б-группы с 15-х по 180-е сутки на 7,07%,
BACKGROUND: Osteoporosis and osteopenias are the most common metabolic diseases of skeleton leading to loss of bone mass, which in turn contributes to increase in the incidence of fractures occur against their background. To note, bone fractures often require not only correction of phosphorus-calcium metabolism, but also bone-plastic operations. AIM: To investigate the structure of the middiaphysis of the humeral bone after plastic surgery of the tibia defect with OK-015 material and substantiate the possibilities of correction of its damages by “Biomin MK”. MATERIALS AND METHODS: The experiment involved 210 male laboratory rats with initial body weight from 135 to 145 g: group A — control, in group B perforation of the tibia, in group C filling of the defect with OK-015 material. In the group D after perforation and in the group E after implantation, “Biomin MK” was used intragastrically through a tube at a dose of 90 mg/kg/day. RESULTS: Perforation of the tibia was accompanied by an increase in resorptive processes and inhibition of bone formation in the diaphysis of the humeral bone with maximum deviations by the 30th day after surgery. The implantation of the OK-015 material was accompanied by aggravation of the identified alterations within 15 days, but in the later period, the structure of the middiaphysis recovered faster. With intragastric administration of “Biomin MK” through a tube after the bone plasty, the structure of the middiaphysis of the humeral bones showed more evident changes by the 7th and 15th day, but by the 30th and 60th day after the implantation, the thickness of the layer of the external circumferential lamellae was greater than in group C by the 3.77% and 4.27%, and the thickness of the internal circumferential lamellae and the diameter of osteons by the 60th day — by 3.51%, 6.46% and 18.64%. CONCLUSIONS: The administration of “Biomin MK” during implantation of OK-015 material into the tibia is accompanied by the restoration of the structure of the middiaphysis of the humeral bones, mainly from the 30th to 60th days after the surgery.
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