<abstract> <p>The scenario of growing microbial resistance and of lack of interest of pharmaceutical companies in developing new antimicrobial drugs jeopardizes the present and the future of the treatment of infectious diseases. Different approaches such as antimicrobial peptides and CRISP-R have been explored to manage this situation, however, they have important limitations such as their high cost. Natural products comprise complex molecular structures for which reports of bacterial resistance are rare. They present specific and/or unspecific mechanisms of action that can be explored to provide safe and effective management of infectious diseases. In this review we assessed phytoextracts with evidence of their benefits for treating infectious diseases in humans and animals, towards the use of data for clinical and experimental purposes. Mechanisms of bacterial resistance to antimicrobials are also discussed.</p> </abstract>
Sunflower oil is known for its therapeutic properties and culinary use. It is an important alimentary source of tocopherol and unsaturated fatty acids, and is used especially for wound healing. Studies indicate that it also has antimicrobial potential. The ozonation of oils of vegetable sources has been explored as a way to enhance their therapeutic properties; however, studies that provide evidence of such benefits are still lacking. In the field of veterinary medicine, such data are even more scarce. In this study, the antimicrobial activity of ozonated sunflower oil was compared to that of non-ozonated oil, in an in vitro system. We used clinical isolates of Escherichia coli, obtained from intrauterine lavages of mares with endometritis. Tests were conducted using the minimum inhibitory concentration method. Our data open doors for discussion on the use of sunflower oil, with or without ozone treatment, for therapeutic purposes in veterinary medicine.
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