ObjectiveTo assess the efficacy of inhaled ciclesonide in reducing the duration of oxygen therapy (an indicator of time to clinical improvement) among adults hospitalised with COVID-19.DesignMulticentre, randomised, controlled, open-label trial.Setting9 hospitals (3 academic hospitals and 6 non-academic hospitals) in Sweden between 1 June 2020 and 17 May 2021.ParticipantsAdults hospitalised with COVID-19 and receiving oxygen therapy.InterventionInhaled ciclesonide 320 µg two times a day for 14 days versus standard care.Main outcome measuresPrimary outcome was duration of oxygen therapy, an indicator of time to clinical improvement. Key secondary outcome was a composite of invasive mechanical ventilation/death.ResultsData from 98 participants were analysed (48 receiving ciclesonide and 50 receiving standard care; median (IQR) age, 59.5 (49–67) years; 67 (68%) men). Median (IQR) duration of oxygen therapy was 5.5 (3–9) days in the ciclesonide group and 4 (2–7) days in the standard care group (HR for termination of oxygen therapy 0.73 (95% CI 0.47 to 1.11), with the upper 95% CI being compatible with a 10% relative reduction in oxygen therapy duration, corresponding to a <1 day absolute reduction in a post-hoc calculation). Three participants in each group died/received invasive mechanical ventilation (HR 0.90 (95% CI 0.15 to 5.32)). The trial was discontinued early due to slow enrolment.ConclusionsIn patients hospitalised with COVID-19 receiving oxygen therapy, this trial ruled out, with 0.95 confidence, a treatment effect of ciclesonide corresponding to more than a 1 day reduction in duration of oxygen therapy. Ciclesonide is unlikely to improve this outcome meaningfully.Trial registration numberNCT04381364.
Since milk is one of the most consumable products of human consumption and in Kosovo, it is one of the most prosperous agriculture branches and the continued support to farmers from the Ministry of Agriculture, European Commission and USID, through which we will offer knowledge about the quality of this milk. Quality milk production is the ultimate goal and goal of any milk producer and processor. On the other hand, the low quality of milk has a negative impact on all segments of the dairy industry, especially in the fresh milk processing segment.Our work provides testing of raw milk samples taken by farmers who send milk to milk collection points and dairies in order to determine the quality of your milk. As a monitoring point we have received the Vita dairy and Aldi dairy in the period January 2017 - October 2018, and we have presented a comparison of their results.
Barley is a plant that occupies an important place in the structure of cultivated plants in Europe. The main use of barley is for brewing beer. Even in Kosovo, the main part of barley production is used in the beer industry. The beer industry in Kosovo produces beer prepared from barley; it is liked by the consumer, not only in Kosovo but also in Albania. Our brewing industry mainly uses locally grown barley. Our farmers have planted the traditional cultivars of barley, but recently and in the future, new cultivars are being introduced, preferring those that give high yields but also with good chemical and technological indicators. The introduction of new cultivars has laid the need for their study, both quantitatively, i.e. for the amount of production per unit of surface area, but also for qualitative indicators. Such a study needs to be undertaken not only because of the new cultivars but also because of the fact that in our country, in our cultivation conditions, there has not been any real study in these directions.
The aim of this paper provides data on the behaviour of some new soft wheat lines created by Agroarfa (Albania), in two cultivation environments, respectively in Lushnje (Albania) and Istog (Kosovo). From the yield data of the lines result noticeable changes in terms of average yield, as well as from line to line. Some of the lines like; AF19-65 and AF-08 do not show significant differences between the two test areas, which shows that these are characterized by a better stability in terms of production. Generally, the lines with higher yields such as AF19-64, AF19-06, etc., are characterized by more pronounced differences between areas
Pasteurized milk products, widely used in dietary diets, are highly popular products in the dairy industry. Safety and control of these products is part of food safety and includes technological processes as well as additional substances approved by the state standard. Additives in pasteurized milk products are used to perform a variety of functions, both to improve their taste, texture and longevity. Notwithstanding this, consumers should not be jeopardized in their health when consuming these foods and the use of these pasteurized milk products is regulated by legislation in different countries and between EU countries, many additives are listed in Directives 94/35 / EC, 94/36 / EC2 and 95/2 / EC3 on dyestuffs, sweeteners, antimicrobial substances, antioxidants, and other additives applied by EU countries. By standard analytical methods they were evaluated for a period of several days from pasteurized milk products obtained from the network of supermarkets in several cities of Kosovo and produced by the most popular Kosovar firms in milk processing. The samples were selected taking into account the storage time and temperature and were analyzed in relation to physico-chemical indicators and the amount of additional substances used in dairy products.
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