Undifferentiated pleomorphic sarcoma constitutes less than 5 % of all sarcomas in adults and has been
rarely seen in the breast and is dened as a group of pleomorphic, high-grade sarcomas in which any
attempt to disclose their line of differentiation has failed . Most undifferentiated pleomorphic sarcomas(UPS) have occurred in
their sixth and seventh decades of life and very rarely in adolescents and adults.
We report a case of 24 year old female presented with painless lump in right breast and rapidly increasing in size for last 5
months. Iinitial diagnosis was made as sarcoma breast on the basis of physical and radiological examination. After that total
mastectomy was done without axillary lymph node dissection, as lymphatic spread is very rare. But without histopathological
examination and most importantly IHC-panel, it is impossible to make a denitive diagnosis of UPS breast.
Clear cell carcinoma of endometrium is a rare but aggressive malignancy with high predisposition of early extra-uterine
spread. It commonly presents with vaginal bleeding or discharge. Less commonly, it may be diagnosed subsequent to an
abnormal pap smear. Endometrial biopsy is ideally the first step for early diagnosis of such unfavourable endometrial
cancer. Histopathological diagnosis is mandatory to confirm the presence of clear cells in the endometrial sample
before planning the course of treatment. Here, we report a case of a postmenopausal woman who presented with vaginal
bleeding without a specific medical history. Endometrial biopsy was done and sample was sent to our department of
Pathology for histopathological diagnosis. We report the case from a histopathological perspective with a brief review of
the relevant literature.
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