Introduction: Patients with transient ischemic attack (TIA) and minor stroke demonstrate cognitive impairment, and a four-fold risk of late-life dementia. Aim: To study the extent to which the rates of brain volume loss in TIA patients differ from healthy controls and how they are correlated with cognitive impairment. Methods: TIA or minor stroke patients were tested with a neuropsychological battery and underwent T1 weighted volumetric magnetic resonance imaging scans at fixed intervals over a 3 years period. Linear mixed effects regression models were used to compare brain atrophy rates between groups, and to determine the relationship between atrophy rates and cognitive function in TIA and minor stroke patients. Results: Whole brain atrophy rates were calculated for the TIA and minor stroke patients; n = 38 between 24 h and 18 months, and n = 68 participants between 18 and 36 months, and were compared to healthy controls. TIA and minor stroke patients demonstrated a significantly higher whole brain atrophy rate than healthy controls over a 3 years interval ( p = 0.043). Diabetes ( p = 0.012) independently predicted higher atrophy rate across groups. There was a relationship between higher rates of brain atrophy and processing speed (composite P = 0.047 and digit symbol coding P = 0.02), but there was no relationship with brain atrophy rates and memory or executive composite scores or individual cognitive tests for language (Boston naming, memory recall, verbal fluency or Trails A or B score). Conclusion: TIA and minor stroke patients experience a significantly higher rate of whole brain atrophy. In this cohort of TIA and minor stroke patients changes in brain volume over time precede cognitive decline.
Background In contrast with the setting of acute myocardial infarction, there are limited data regarding the impact of diabetes mellitus on clinical outcomes in contemporary cohorts of patients with chronic coronary syndromes. We aimed to investigate the prevalence and prognostic impact of diabetes according to geographical regions and ethnicity. Methods and results CLARIFY is an observational registry of patients with chronic coronary syndromes, enrolled across 45 countries in Europe, Asia, America, Middle East, Australia, and Africa in 2009–2010, and followed up yearly for 5 years. Chronic coronary syndromes were defined by ≥1 of the following criteria: prior myocardial infarction, evidence of coronary stenosis >50%, proven symptomatic myocardial ischaemia, or prior revascularization procedure. Among 32 694 patients, 9502 (29%) had diabetes, with a regional prevalence ranging from below 20% in Northern Europe to ∼60% in the Gulf countries. In a multivariable-adjusted Cox proportional hazards model, diabetes was associated with increased risks for the primary outcome (cardiovascular death, myocardial infarction, or stroke) with an adjusted hazard ratio of 1.28 (95% confidence interval 1.18, 1.39) and for all secondary outcomes (all-cause and cardiovascular mortality, myocardial infarction, stroke, heart failure, and coronary revascularization). Differences on outcomes according to geography and ethnicity were modest. Conclusion In patients with chronic coronary syndromes, diabetes is independently associated with mortality and cardiovascular events, including heart failure, which is not accounted by demographics, prior medical history, left ventricular ejection fraction, or use of secondary prevention medication. This is observed across multiple geographic regions and ethnicities, despite marked disparities in the prevalence of diabetes. ClinicalTrials identifier ISRCTN43070564
Modern technologies has changed our life, such as everywhere computing communication and internet. Number of transistors increasing in a system day by day and this trend will continue further. The wire connection is easily breakable and not a reliable technology in field of networks. In conventional network dedicated wired path is used among the intellectual property (IP) core for the purpose of communication and due to this wired connection network is not reliable and not scalable. Network-on-Chip Architecture was introduced to solve these problems and gave notable improvements over conventional bus and crossbar communication architectures. Many companies prefer third party vendors for the development of their design in order to reduce the cost. It gives advantage but due to the access of design anyone can do changes at any stage of development cycle. This type of malicious modification of hardware during design or fabrication process is known as Hardware Trojan (HT). It can change the functional behavior of a system or may leak the secret information of critical application which results in degradation of system performance. The proposed research is based on combination of Error Correcting Code and Junction router to detect and avoid HT which can be used for reliable communication in NoC architecture. Simulation results showed good performance of proposed algorithm in term of Packet Latency and Reliability.
Medicinal plants are used since the dawn of human civilization for therapeutic purpose. New bioactive natural compounds came into existence due to the extensive use of herbal remedies and therapeutic preparations obtained from medicinal plants. In the review attempt has been made to collect the data on the medicinal and pharmacological properties of Santalum album. Data has been collected using different search engines (google scholar, Pubmed, Elsevier, Springer link, science direct), books, Literature reviews. Santalum album is commercially important plant belong to Santalaceae family. Santulum album commonly known as sandal wood is well known all over the world for its most expensive stem. It has many therapeutic efficacy and used in different ailments. It is Disinfectant in genitourinary and bronchial tracts, diuretic, expectorant and stimulant. Sandalwood is the precious tree cultured in India. S. album is mainly grown for its timber and fragrant oil. Like rosewood and cinnamon wood, it is also an aromatic wood. The powder of wood is used medicinal, culture and religious purpose. Therefor it is used to make perfumes, in cosmetic industry, in pharmaceutical industries and aromatherapy. In pharmacology sandalwood acts as coolant, sedative, astringent. In the present review we discuss the medicinal and pharmacological potential of Santalum album.
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