Bartter's syndrome is characterized by hypokdlemic metabolic alkalosis, hyperrcninemia, aldostcronlsm. normotcnsion and hyperplasia of he juxtdglomerul~r apparatus (JGA). A retruspectlvc analysis of four infants, ages 5 to 8 months (6' 1.2 m.) who were fed milk free soy isolate formula (N) for 5 ; 1.2 months wd5 undertaken. All the patients sought medical attention for failure to thrive (FTT) and all of them had signs and symptoms undistinguishable of BS, namely severe metdhol~c acidos~s (pH 7.62: 0.6). HC03 40 ' 3 (BE + 17 ? 3). Hypuchloremia (C1 72 ' 9 mEqil Hypokalemici (K 2.8 + 0.3 mEqll.) Hypercd1cemi.t was observed in 2 patients. One patient had microscopic hematuria; 3 pat~ents had renin levels in excess of 300 nglml/hr associated with high aldosterone levels in the presence of normutension. Initial urinary electrolytes showed continuous moderate K and Na, wlth mlnlmal chloride loss. Formula change and intravenous NaCl lead to rapid correction of abnormal laboratory results. The severe metabolic abnormalities observed in these infants cannot be explained solely by the low chloride levels in this formula, nor the high renin and aldosterone or the microscopic hemdturia. Prostaglandin-like substances, or precursors of them should be taken into 'onsideratin. Prospective studies of this occurrence mdy help to develop an animal model to further understandlrtg of BS.
URINARY TRACT INFECTIONSHORT TERFl TREt~TMEliT OF CllILDHOOD UTI. Forty children were randomly assigned a 3-or 10-days treatment with TPlP/SDZ, administered twice daily in a dose of 16/4 m g per k g bw per day. They ell had symptomatic lower UTIs with significant bacteriuria. Temperature below 38'~ and E S H below 10 mm in the first hour excluded the existence of an upper UTI. Results: All children were abacteriuric at control -three days after the cessation of therapy. Out of 17 children on three days of therapy, infection recurred in two, two months after the index infection. Out of 23 patients treated for 10 days, infection recurred also in two patients, two and five m o n~h 5 after the index infection. It is concluded from this study that in children with an acute lower UTI, treatment with TflP/SDZ for three days is ePfective in eradicating the bacteria and that the treatment does not increase the risk of early recurrence as compared to treatment for 10 days.
9The pk antigen as receptor for pyelonephritic E.coli Kallenius, G., Mallby, R., Lundblad, A . , Winberg, J., Department of Pediatrics, Karolinska Hospital, Karolinska Institute, Stockholm, Department of Bacteriology, National Bacteriological Laboratory, Stockholm and Department of Clinical Chemistry, University Hospital, Lund, Sweden.The specific D-mannose resistant agglutination of hunan erythrocytes (!1RHAhUr,,) observed in uropathogenic E.coli strains was invest~gated. 14 consecutive pyelone?hritic E.coli strains were studied. All agglutinated human er:rthrocytes irrespective of their ABO or Lewis bloodgroups. Veither was the HA affected by the content of H or I antigens on the erythroc...