The pure boundary element method (BEM) is effective for the solution of a large class of problems. The main appeal of this BEM (reduction of the problem dimension by one) is tarnished to some extent when a fundamental solution to the governing equations does not exist as in the case of nonlinear problems. The easy to implement local point interpolation method applied to the strong form of differential equations is an attractive numerical approach. Its accuracy deteriorates in the presence of Neumann-type boundary conditions which are practically inevitable in solid mechanics. The main appeal of the BEM can be maintained by a judicious coupling of the pure BEM with the local point interpolation method. The resulting approach, named the LPI-BEM, seems versatile and effective. This is demonstrated by considering some linear and nonlinear elasticity problems including multi-physics and multi-field problems.
Biomaterials applied to the epicardium have been studied intensively in recent years for different therapeutic purposes. Their mechanical influence on the heart, however, has not been clearly identified. Most biomaterials for epicardial applications are manufactured as membranes or cardiac patches that have isotropic geometry, which is not well suited to myocardial wall motion. Myocardial wall motion during systole and diastole produces a complex force in different directions. Membrane or cardiac patches that cannot adapt to these specific directions will exert an inappropriate force on the heart, at the risk of overly restricting or dilating it. Accurately characterizing the mechanical properties of the myocardial wall is thus essential, through analysis of muscle orientation and elasticity. In this study, we investigated the Hertz contact theory for characterizing cardiac tissue, using nanoindentation measurements to distinguish different patterns in the local myocardium. We then evaluated the predictive accuracy of this model using Finite Element Analysis (FEA) to mimic the diastolic phase of the heart. Our results, extracted from instrumented nanoindentation experiments in a liquid environment using five pig hearts, revealed variations in elasticity according to the local orientation of the myocardial tissue. In addition, applying the Finite Element Method (FEM) in our model based on transverse isotropy and local tissue orientation proved able to accurately simulate the passive filling of a left ventricle (LV) in a representative 3D geometry. Our model enables improved understanding of the underlying mechanical properties of the LV wall and can serve as a guide for designing and manufacturing biomedical material better adapted to the local epicardial tissue.
Understanding the deformation of arterial walls under loading is essential for the definition of some new therapeutic protocols. This requires the modeling of the mechanical behavior of the artery wall. In this work, in order to account for the microstructure, each of the conventional three layers of the artery is assumed to behave like a dilatation elastic solid. The resulting compound is then submitted to various loads and the response analyzed in order to highlight the contribution of the microstructure. Finally, the impact of a localized zone of microstructure modification on the overall deformation is investigated.
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