Aldehydes react with silyl ethers or the corresponding alcohols and allylsilanes in the presence of catalytic amounts of 2,4-dinitrobenzenesulfonic acid (DNBA) to provide a wide range of homoallylic ethers in moderate to high yields.
Acetaldehyd als Nucleophil in der asymmetrischen Katalyse: Ein Silylprolinol‐Derivat (TMS=Trimethylsilyl) katalysiert die Michael‐Addition von Acetaldehyd mit aromatischen und aliphatischen Nitroolefinen in hervorragenden Enantioselektivitäten. Die Reaktion wurde zur Synthese dreier pharmazeutischer Wirkstoffe und eines enantiomerenreinen 3‐substituierten Pyrrolidins angewendet.
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