The coronavirus disease 2019 (COVID-19) is the latest biological hazard for the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Even though numerous diagnostic tests for SARS-CoV-2 have been proposed, new diagnosis strategies are being developed, looking for less expensive methods to be used as screening. This study aimed to establish salivary vibrational modes analyzed by attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy to detect COVID-19 biological fingerprints that allow the discrimination between COVID-19 and healthy patients. Clinical dates, laboratories, and saliva samples of COVID-19 patients (N = 255) and healthy persons (N = 1209) were obtained and analyzed through ATR-FTIR spectroscopy. Then, a multivariate linear regression model (MLRM) was developed. The COVID-19 patients showed low SaO2, cough, dyspnea, headache, and fever principally. C-reactive protein, lactate dehydrogenase, fibrinogen, d-dimer, and ferritin were the most important altered laboratory blood tests, which were increased. In addition, changes in amide I and immunoglobulin regions were evidenced in the FTIR spectra analysis, and the MLRM showed clear discrimination between both groups. Specific salivary vibrational modes employing ATR-FTIR spectroscopy were established; moreover, the COVID-19 biological fingerprint in saliva was characterized, allowing the COVID-19 detection using an MLRM, which could be helpful for the development of new diagnostic devices.
The coronavirus disease 2019 (COVID-19) is the latest biological hazard for the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Numerous diagnostic tests for SARS-CoV-2 have been used, which are expensive and require specialized personal. So, new diagnosis strategies are being developed, looking for less expensive methods which could be used as screening for better spread control. Many researchers have described the use of saliva as a potential indicator of COVID-19, and even the same patient could carry out its collection. In this sense, this study aimed to establish specific salivary vibrational modes analyzed by attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy to detect COVID-19 biological fingerprints that allow the discrimination between COVID-19 and healthy patients. Previous written informed consent, clinical dates, laboratories, and saliva samples of COVID-19 patients (n = 255) and healthy persons (n = 1209) were obtained and analyzed through ATR-FTIR spectroscopy. Then, a multivariate linear regression model (MLRM) was developed. The COVID-19 patients showed low SaO2, cough, dyspnea, headache, and fever principally. Obesity was the main comorbidity. Various laboratory blood tests were altered. In the FTIR spectra analysis, changes in amide I and immunoglobulin regions were evidenced, and the MLRM showed clear discrimination between both groups. Specific salivary vibrational modes employing ATR-FTIR spectroscopy were established; moreover, the COVID-19 biological fingerprint in saliva was characterized, allowing the detection for COVID-19 using an MLRM, once it helps to reduce the number of variables, which could be helpful in the future development of diagnostic devices in a faster and cheaper way.
Background: Intestinal obstruction is a common late complication of Roux-en-Y gastric bypass surgery, most commonly due to internal herniation or anastomotic strictures. Bezoars are a rare cause of obstruction in this setting, with very few cases reported in literature. Case Report:The authors present the case of a 39-year-old female patient who underwent a laparoscopic Roux-en-Y gastric bypass for the treatment of severe obesity 9 years before her admission. Initially she weighed 140 kg, her body mass index was 50.8 kg/m 2 , and she didn't have any known comorbid conditions. She was admitted to the emergency department at the hospital with abdominal pain, distention, nausea, and vomiting over 20 episodes that started 16 hours before her admission. After workup, a decision was made to perform a laparoscopic exploration. An 8-cm phytobezoar obstructing the common channel of the bypass was found; it was composed mostly of orange fibers and slices. It was extracted via enterotomy. Results:In the postoperative period the obstructive syndrome was resolved, the patient was started on clear liquids in postoperative day 2 and sent home on postoperative day 5. The instructions were not to ingest large amounts of fiber and chewing on her meals. Her recovery was uneventful. Conclusions:To the best of the authors' knowledge there are about 15 reported cases of bezoar formation in patients who underwent Roux-en-Y gastric bypass surgery. As this procedure is more frequently performed worldwide, an increase on these types of cases is expected.
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