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A new series of benzamido alkyl naphthols were synthesized from the multi-component reaction of 4-(3′-methylthioureido)benzamide, aromatic aldehydes and 2-naphthol. Molten tetrabutyl ammonium bromide was used as a very efficient medium for this reaction while the use of common organic solvents gave no or poor yields. This method is an interesting instance of using molten salt as a medium in multicomponent reactions.

A series of new fluorine containing 4-amino-pyrimidine-5-carbonitrile derivatives has been synthesised from the three-component reaction of malononitrile, fluorinated aldehydes or ketone and N-unsubstituted amidines. The reaction occurs in water at reflux and is microwave assisted. This method provides a new route to produce fluorinated pyrimidine derivatives in good to excellent yields.

Pyrimidine derivatives R 0510Three-Component Synthesis of Fluorinated Pyrimidine Carbonitrile Derivatives under Thermal Aqueous Conditions. -New fluorine-containing 4-aminopyrimidine-5-carbonitrile derivatives are synthesized by three-component reaction of malononitrile with fluorinated carbonyl compounds and amidines under both thermal and microwave-assisted conditions. -(SHEIBANI*, H.; SAIDI, K.; SALJOOGHI, A. S.;