Pendahuluan. Adanya polimorfisme gen angiotensin converting enzyme (ACE) diduga berperan terhadap penyakit kardiovaskular, termasuk coronary slow flow phenomenon (CSFP). Polimorfisme gen ACE juga merupakan faktor penting dalam peningkatan kadar angiotensin II. Penelitian ini bertujuan untuk mengetahui pengaruh polimorfisme insersi/delesi (I/D) 287 bp alu repetitive sequence pada intron 16 gen ACE dan kadar angiotensin II terhadap CSFP di RSUP Dr. Mohammad Hoesin Palembang.Metode. Studi kasus kontrol dimulai dari Juli 2019 sampai Juli 2020 di RSMH Palembang dengan masing-masing 32 subjek pada kelompok kasus (pasien CSFP) dan kontrol (non-CSF). Penelitian ini menggunakan sepasang primer dan satu kali PCR untuk deteksi polimorfisme I/D gen ACE. Analisis genetik dilakukan di Laboratorium Bioteknologi Fakultas Kedokteran Universitas Sriwijaya. Data yang terkumpul dianalisis dengan uji korelasi Spearman.Hasil. Dari 32 subjek kelompok CSFP, didapatkan distribusi genotip II pada 17 subjek (53,1%), genotip ID pada 14 subjek (43,8%), dan genotip DD pada 1 subjek (3,1 %). Sementara dari 32 subjek kelompok non-CSF, didapatkan distribusi genotip II pada 11 subjek (34,4%), genotip ID pada 13 subjek (42,2%), dan genotip DD pada 9 subjek (14,1%). Nilai median kadar angiotensin II pada kelompok CSFP 58 pg/mL dan pada kelompok Non-CSF 32,8 pg/mL. Hasil analisis menunjukkan terdapat pengaruh kadar angiotensin II terhadap kejadian CSFP (p=0,001). Analisis lebih lanjut menunjukkan adanya korelasi kadar angiotensin II dengan polimorfisme I/D 287 bp alu repetitive sequence pada intron 16 gen ace (p=0,030, r=0,822). Simpulan.Terdapat korelasi antara polimorfisme I/D 287 bp alu repetitive sequence pada intron 16 gen ACE dan kadar angiotensin II terhadap kejadian coronary slow flow phenomenon di Rumah Sakit Dr. Mohammad Hoesin Palembang.
A lot of hypertensive patients require two or more antihypertensive drugs to control and maintain normal blood pressure. Combination of antihypertension is recommended either as first or second line treatment. Among available antihypertension medications, combination of renin-angiotensinaldosteron (RAAS) inhibitor with calcium channel blocker or diuretics are more recommended as they have sinergistic clinical and biomolecular effects.Furthermore, single pill dosage is associated with higher patients compliants and lower faults incidence in medication. Severeal fixed-dose combinations are currently available in the market to give easier hypertension control and patients compliants. This short review focus on combination of perindropril and amlodipine
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