No abstract

No abstract

Tecoma stans is a plant traditionally used in Mexico for the control of diabetes. Amongst the alkaloids isolated from the plant harvested in Egypt, Tecomine was shown to be one of the compounds responsible for the hypoglycemic action. Given the interest in substances able to treat type II diabetes, we isolated the main alkaloids present in the plant growing in Egypt and Brazil and tested them in vivo on db/db mice. Contrary to previous literature reports on different animal models, Tecomine was unable to modify glycemia; the only effect seen being a decrease in plasma cholesterol levels. On the contrary, when tested in vitro on glucose uptake in white adipocytes, the compound showed a marked effect. The two other alkaloids isolated, namely 5b-Hydroxyskitanthine, early called Base C, and Boschniakine were inactive both in vivo and in vitro assays.

No abstract

No abstract

No abstract

i t z k i ' ' I n s t i t u t o d e Q u i m i c a , U n i v e r s i d a d e d e Sso P a u l o , 0 5 5 0 8 Sso P a u l o , S P , B r a z i l :'Department of C h e m i s t r y , B a r -I l a n U n i v e r s i t y , Ramat-Gan, I s r a e l ; ' I n s t i t u t f i i r Allgemeine B o t a n i k und B o t a n i s c h e r G a r t e n , U n i v e r s i t a t Hamburg, 2 0 0 0 Hamburg 5 2 , F.R. Germany Received : 12/05/1986 Key Word I n d e x -W e l w i t s c h i a m i r a b i l i s ; G n e t a t a e : g n e t i n s ; o x i d a t i v e r e s v e r at r o l o l i y o m e r s : c h e m o s y s t e m a t i c s . ~~ ABSTRACT and para-hydroxybenzaldehyde, b e s i d e s two d e h y d r o r e s v e r a t r o l dimers g n e t i n s F and G and two d e h y d r o r e s v e r a t r o l trimers g n e t i n s H and I f o r which s t r u c t u r e s a r e p r o p o s e d . O t h e r o x i d a t i v e r e s v e r a t r o

Alkaloids Alkaloids U 0600Characterization and Pharmacological Actions of Tecostanine, an Alkaloid of Tecoma stans. -The alkaloid (I), named tecostanine, is isolated from the leaves of the title plant. The structure of a salt derived from (I) with methyl iodide is determined by X-ray analysis. -(COSTANTINO*, L.; LINS, A. P.; BARLOCCO, D.; CELOTTI, F.; EL-ABADY, S. A.; BRUNETTI, T.; MAGGI, R.; ANTOLINI, L.; Pharmazie 58 (2003) 2, 140-142; Dip. Sci. Farm., Univ. Modena, I-41100 Modena, Italy; Eng.) -K. Schneider 24-180