Genetic studies report the existence of a mutant allele ~32 of CCR5 chemokine receptor gene at high allele frequencies (rvlO %) in Caucasian populations. The presence of this allele is believed to provide partial or full resistance to HIV. In this study, we look at the impact of education, temporarily effective vaccines and therapies on the dynamics of HN in homosexually active populations. In our model, it is assumed that some individuals possess an allele (like ~32 of CCR5) that prevents the successful invasion or replication of HN. Our model therefore differentiates by genetic and epidemiological status and naturally ignores the reproduction process. Furthermore, HIV infected individuals are classified as rapid, normal or slow progressors. In this complex setting, the basic reproductive number ~o is derived in various situations. The separate or combined effect of therapies, education and vaccines are analyzed. Our results support the conclusions of Shu-Fang Hsu Schmitz that some integrated intervention strategies are far superior to those based on a single approach .
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.