Background: Psychological factors have been prominently implicated in the causation as well as maintenance of irritable bowel syndrome (IBS). Studies comparing psychiatric morbidity in IBS with healthy controls have reported contrasting findings. The current study was undertaken to assess the prevalence of anxiety and depression in patients with IBS in comparison to healthy controls and to explore the relationship, if any, of anxiety and depression with various subtypes of IBS. Materials and Methods: Fifty consecutive patients of IBS (diagnosed as per Rome III criteria) between 18 and 65 years of age and fifty age- and sex-matched healthy controls were assessed for the presence of anxiety and depression using Hamilton Rating Scale for Anxiety (HAMA) and Hamilton Rating Scale for Depression (HAMD), respectively. Results: The patient group scored higher than controls ( P < 0.001) in both HAMA and HAMD scores. The HAMA scores were significantly higher ( P < 0.001) in the severe IBS group compared to those with moderate IBS. HAMA scores predicted 25.6% ( R 2 = 0.256) of variance in IBS severity scores. However, there was no significant difference between the two groups in terms of HAMD scores. Conclusion: The high prevalence of psychiatric comorbidities such as anxiety and depression in IBS samples in our study provides evidence in favor of proper screening for these disorders in gastrointestinal clinics. Recognition and treatment for these comorbidities can improve the quality of life as well as overall outcomes.

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