The present study provided the scientific evidence, where P. fulgens rich in polyphenolic components possess remarkable wound healing activities, thereby supporting the traditional claims.
Aim:The aim of this study was to investigate the antioxidant and hepatoprotective effects of the polyherbal formulation (PHF)containing Cajanus cajan (L.)Millsp., Lawsonia inermis L. Linn, Mimosa pudica L., Uraria picta (Jacq.)DC. and Operculina turpethum (L.)Silva Manso on carbon tetrachloride (CCl4)induced acute liver damage in albino rats.Materials and Methods:The groups of animals were administered with PHF at the doses 100, 200 and 400 mg/kg b.w. (per oral [p.o.])once in a day for 7 days and at day 6th and 7th the animals were administrated with Carbon tetrachloride (1.0 mL/kg b.w. 50% v/v with olive oil,; p.o.). The effect of PHF on serum glutamine pyruvate transaminase (SGPT), serum glutamine oxaloacetate transaminase, alkaline phosphatase (ALP)and total bilirubin were determined in CCl4 - induced hepatotoxicity in rats. Further, the effects of PHF on glutathione (GSH), superoxide dismutase (SOD)level and lipid peroxidation (LPO)activity were also investigated.Results:The results demonstrated that PHF (400 mg/kg b.w.)significantly reduces the CCl4 induced increase in level of serum SGPT, serum ALP and total bilirubin. PHF (400 mg/kg b.w.)prevents the depletion level of GSH and decrease in the activity of SOD in CCl4 -induced liver injury in rats. In addition, PHF also showed a significant decrease in the LPO levels signifying the potent antioxidant activity.Conclusion:All our findings suggest that PHF could protect the liver cells from CCl4 - induced liver damages and the mechanism may be through the anti-oxidative effect of PHF.
This study aims to assess the acute toxicity of commercial-grade Cypermethrin (10% EC) and evaluate the hematological and behavioral alterations in a freshwater fish Channa punctatus upon short-term exposure to Cypermethrin. A four-day static acute toxicity test was performed to estimate the median lethal concentration (LC50) value of Cypermethrin. During the acute toxicity test, the behavior of the control and cypermethrin exposed fish was critically observed and recorded. After completing the acute toxicity test, the hematological effects of Cypermethrin in C. punctatus were evaluated using two sublethal dosages (0.08 mg/L and 0.12 mg/L). Results of the study revealed that this pesticide induced significant mortality in C. punctatus with a 96-h L50 value of 0.263 mg/L. Cypermethrin exposed fish showed hyperactivity, irritability, erratic swimming, frequent surface visit, etc. Exposure to sublethal concentrations of Cypermethrin for a short period resulted in a significant decline (P<0.05) in total erythrocytes count (TEC), packed cell volume (PCV), mean corpuscular volume (MCV), and hemoglobin (Hb) concentration as compared to control groups. In contrast, pesticide-exposed groups had a significant increase (P<0.05) in mean corpuscular hemoglobin concentration (MCHC) and total leucocyte count (TLC). It is apparent from the results of the study that this commercial formulation is toxic to the studied fish. This study also revealed hematological and behavioral alterations in C. Punctatus which could be used as biomarkers for incipient Cypermethrin intoxication.
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