Pyridine derivatives R 0380 2,4,6-Trisubstituted Pyridines: Synthesis, Topoisomerase I and II Inhibitory Activity, Cytotoxicity, and Structure-Activity Relationship. -A series of 16 target compounds (III) is prepared. Structure-activity relationship studies indicate that a 4-pyridinyl unit at the 2-position of the central pyridine plays a key role. -(BASNET, A.; THAPA, P.; KARKI, R.; NA, Y.; JAHNG, Y.; JEONG, B.-S.; JEONG, T. C.; LEE, C.-S.; LEE*, E.-S.; Bioorg. Med. Chem. 15 (2007) 13, 4351-4359; Coll. Pharm., Yeungnam Univ., Kyongsan 712-749, S. Korea; Eng.) -Kieslich 42-131
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