The Philippines, being an archipelagic country, is well known for its relatively strong and persistent currents in its straits and channels. Harnessing these strong currents for tidal in-stream energy will greatly help reduce the dependency of the country to imported oil for power generation. The developed energy potential (EP) metric was validated using sites identified by the Philippines' Department of Energy (DOE) as having high potential for ocean tidal energy. This metric provides a less complex methodology with acceptable accuracy for tidal instream resource assessment that makes use of tide height difference at the boundaries of a channel. Using this enables geographic information system (GIS) based data to increase turnaround time for site suitability, technology matching, and feasibility studies for ocean renewable energy installations.
Ultraviolet radiation (UVR) is proven to be an effective treatment for psoriasis yet it needs to be carefully controlled since it is a widely known carcinogen. Due to the time-consuming, expensive and hazardous nature of clinical tests on actual patients, the range of possible values for the optimal regimen set has not yet been thoroughly explored. An agent-based model was constructed in order to study the complex role of UVR in psoriasis phototherapy, including possible contribution to the formation of skin cancers. The treatment progression of the simulated psoriasis undergoing UVR phototherapy was monitored weekly and compared with the corresponding clinical data. For model calibration, a single-objective optimization via genetic algorithm was employed that aimed to minimize the discrepancy between the model output and the expected clinical result. After fitting and validation, the model was then subjected to multi-objective evolutionary optimization using Non-dominated Sorting Genetic Algorithm-II (NSGA-II) in order to suggest sets of optimal UVR phototherapy regimen for psoriasis taking into account the safety, clearance time as well as aggressiveness of the therapy. Results show a good model fit against clinical data and gave some plausible sets of dosimetry for UVR phototherapy that maximize its therapeutic efficacy while minimizing the associated skin cancer risk.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.