This paper develops a local Kriging meshless solution to the nonlinear 2 + 1-dimensional sine-Gordon equation. The meshless shape function is constructed by Kriging interpolation method to have Kronecker delta function property for the two-dimensional field function, which leads to convenient implementation of imposing essential boundary conditions. Based on the local Petrov–Galerkin formulation and the center difference method for time discretization, a system of nonlinear discrete equations is obtained. The numerical examples are presented and the numerical solutions are found to be in good agreement with the results in the literature to validate the ability of the present meshless method to handle the 2 + 1-dimensional sine-Gordon equation related problems.