An operationally simple C–SCN and C–SeCN bond formation technique to generate different SCN/SeCN substituted 4-quinolone derivatives using NH4SCN/KSeCN in excellent yields was developed.
An operationally simple sodium iodide-mediated
C–S and C–Se
bond formation protocol involving substituted 4-quinolone and thiols/diselenide
to generate different ArS/ArSe-substituted 4-quinolone derivatives
in excellent yields was developed. The versatility of this methodology
has been successfully demonstrated by extension of the suitable reaction
conditions to both substrates having different substituents. This
regioselective C–H bond activation approach provides a direct
access of structurally diverse 3-sulfenylated/selenylated 4-quinolone
derivatives. Moreover, this new method proceeds without a transition-metal
catalyst and prerequisite NH protection of 4-quinolone derivatives.
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