Oleuropein (OLE), the main constituent of olea oleuropea, displays pleiotropic beneficial effects in health and disease, which are mainly attributed to its antiinflammatory and cardioprotective properties. Several food supplements and herbal medicines contain OLE and are available without a prescription. This study investigated the effects of OLE on the main CYPs catalyzing the metabolism of many prescribed drugs. Emphasis was given on the role of peroxisome proliferatoractivated receptor alpha (PPARα), a nuclear transcription factor regulating numerous genes including CYPs. 129/Sv wild-type and Ppara-null mice were treated with OLE for six weeks. OLE induced Cyp1a1,
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