Tujuan: Menganalisis perbedaan kadar IL-10 antara preeklampsia tipe dini dan preeklampsia tipe lambat. Bahan dan Metode: Penelitian ini melibatkan 56 wanita hamil yang terbagi menjadi empat kelompok, yaitu wanita hamil normal usia kehamilan 30-34 minggu, wanita hamil normal usia > 34 minggu, preeklampsia berat tipe dini (30-34 minggu), preeklampsia berat tipe lambat (> 34minggu). Pemeriksaan IL-10 dilakukan saat penderita masuk rumah sakit dan didiagnosis sebagai preeklampsia dengan menggunakan metode ELISA Hasil: Rerata kadar IL-10 pada kelompok preeklampsia tipe dini (0,37 ± 0,14) lebih rendah dibandingkan kelompok preeklampsia tipe lambat (0,87 ± 0,43) dengan P<0,001. Rerata kadar IL-10 pada kelompok preeklampsia tipe dini (0,37 ± 0,14) lebih rendah dibandingkan kelompok wanita hamil normal usia 30 -34 minggu (0,84 ± 0,42) dengan P<0,001. Tidak didapatkan perbedaan rerata kadar IL-10 pada kelompok preeklampsia tipe lambat (0,87 ± 0,43) dibandingkan kelompok wanita hamil normal usia > 34minggu (0,75 ± 0,68) P=0,22. Simpulan: Keadaan inflamasi berat terjadi pada preeklampsia berat tipe dini Kata Kunci : preeklampsia tipe dini, preeklampsia tipe lambat, IL-10Objectives: To analyze the difference of IL-10 concentration in early and late onset of preeclampsia. Materials and Methods: Cross-sectional analytic study was conducted on 56 pregnant women, divided into four groups : one groups of normal pregnant women with >30-34 weeks of gestation, one group of normal pregnant women with >34 weeks of gestation, one group of early onset preeclampsia (30-34 weeks), one group of late onset of preeclampsia (>34 weeks). Plasma IL-10 concentration examination was collected patient admitted in hospital and diagnosed preeclampsia. Plasma IL-10 was determined by ELISA. Results: Mean plasma IL-10 concentration on early onset preeclampsia group (0,37±0,14) was lower than late onset preeclampsia group (0,87 ± 0,43), (p<0,001). Mean plasma IL-10 concentration on early onset preeclampsia group (0,37 ±0,14) was lower than normal pregnant women with >30-34 weeks of gestation (0,84 ± 0,42), (p<0,001). Median plasma IL-10 concentration on late onset preeclampsia group (0,87 ±0,43) was higher than normal pregnant women with >34 weeks of gestation (0,75 ± 0,68), but not statistically significant (p=0,22). Conclusion: Severe inflammation happened in early onset preeclampsia.
Pregnancy with diabetic ketoacidosis (DKA) increases maternal and perinatal morbidity and mortality. DKA is a rare complication of pregestational diabetes mellitus (DM) or gestational diabetes mellitus (GDM) during pregnancy. However, it could be life-threatening for the mother and fetus without correct diagnosis and treatment. This paper reports a case of DKA in 25 years old Female with 26/27 weeks gestational ages. This was the second pregnancy with bad obstetric history. The patient has a history of DM from a previous pregnancy. The diagnosis of DKA is based on the presence of hyperglycemia, ketone in urine, and metabolic acidosis. After aggressive fluid replacement, intravenous insulin therapy, correction of acidosis and electrolyte imbalance, the patient showed significant improvement. The baby was born spontaneously induced by oxytocin drip, with a birth weight of 900g, APGAR scores 0, and maceration grade 2. After being treated for six days in the intensive care unit and observed for three days in the ward, the patient was allowed to be outpatient in good condition. Rapid restoration of glycemic control is essential to prevent death in pregnant women with diabetes mellitus diabetic ketoacidosis.
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