IAP is involved in the maintenance of normal gut microbial homeostasis and may have therapeutic potential against dysbiosis and pathogenic infections.

The aim of the study was to determine the prevalence of abnormal uterine bleeding and its various patterns from the gynecologists across the country and the preferred therapy in the management of AUB. Material and Methods:The survey was conducted amongst 141 gynecologists across the country. Information was collected by filling up a questionnaire that contained information regarding menstrual cycle irregularities, preferred therapy and alternatives which can be preferred over hormonal prescriptions in case of therapy failure. Statistical data analysis was performed with Microsoft excel 2010 and expressed in percentages. Results: Prevalence of AUB as per this survey is in line with the global data which states that overall prevalence fluctuates in between 10-30%. In this survey, doctors reported 32.72% of females visit their clinic due to AUB. Females of reproductive age group accounted for a major percentage of menstrual irregularities and the most common condition quoted was menorrhagia in 16.06%. Doctors also shared their experience in terms of preferred therapy in the management of AUB and also the percentage of discontinuation/refusal by females for hormonal therapy. Conclusion:The result of the study concluded that significant number of female have issue of abnormal uterine bleeding and limitations of existing therapy leading to discontinuation/refusal opens the door for exploring still safer options in managing AUB.

No abstract

Worldwide diabetes mellitus is highly prevalent and economically devastating illness. This study was a post marketing surveillance (PMS), non-randomized, open, non-comparative, mono-centric study. The drug administered was a fixed dose combination of voglibose 0.2 mg; glimepiride ½ mg and metformin 500 mg sustained release (SR). Fifty type 2 diabetic patients were given fixed dose combination twice daily with major meals for 3 months. Baseline value was recorded for glycated haemoglobin (HbA1c), fasting plasma glucose (FPG) and post prandial blood glucose/hyperglycemia (PPHG) level. There was significant decrease from baseline in HBA1c value 10.6 ± 1.3 vs. 6.6 ± 0.4 (P< 0.0001), FPG levels 208.33mg/dl vs. 118.06 (P< 0.0001), and PPHG levels 360.14 mg/dl vs. 168.36, (P< 0.0001) after 3 months of treatment. The combination was found to be effective in controlling both fasting and post prandial glucose level and was well tolerated. Investigator commented that the use of triple drug combination is a good option in the management of type 2 diabetes which controls both fasting as well as post prandial blood glucose and ultimately HbA1c values.