The repertoire and timing of gestures accompanying speech were compared in children with specific language impairment (SLI), aged 5-10 years, in typically developing peers (CA), individually matched on age and nonverbal IQ, and in younger language-matched (LM) children. They were videotaped in two tasks, recounting a cartoon and describing their classroom. Three types of gestures were coded -iconics, deictics and beats -and the synchrony of these gestures with speech was examined in terms of number of words encompassed, grammatical speech category at gesture onset, and relationship of iconic gestures to the concept expressed in speech. All groups used more deictic gestures in the classroom description task. SLI children differed from the comparison children only in their use of iconic gestures. They produced somewhat more of these, used them more often to replace words, and began them more often on a noun phrase object. Otherwise, language proficiency, at least as measured by standardized tests, did not appear to impact the gestural system. The fact that, for all groups, most iconic and deictic gestures began on the noun phrase subject indicates a close synchrony between gesture and speech onset.
Fragile X syndrome is caused by CGG trinucleotide repeat expansion within the fragile X mental retardation 1 gene, when repeat number exceeds 200. The typical psychiatric profile of fragile X syndrome patients includes cognitive and behavioral deficits, psychiatric comorbidity, and autistic characteristics. Specific psychiatric features have not yet been clarified, specifically in relationship to age and genetic characteristics. The objective of this study was to characterize psychiatric comorbidities in subjects with fragile X syndrome at different ages. Subjects with fragile X syndrome and their unaffected siblings were recruited and their parents filled out functional-behavioral and psychiatric comorbidities questionnaires. Adolescents with fragile X syndrome showed decreased prevalence of functional-behavioral deficits. Incidence and severity of most psychiatric comorbidities were lower in older subjects. Incidence of generalized anxiety disorder increased with age in the fragile X syndrome group. The typical profile of patients with fragile X syndrome changes with age. Unaffected siblings exhibit anxiety and motor tics.
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