Eosinophilic esophagitis (EoE) is an allergic inflammatory condition of the esophagus associated with elevated numbers of eosinophils. Disease diagnosis and monitoring require determining the concentration of eosinophils in esophageal biopsies, a time-consuming, tedious and somewhat subjective task currently performed by pathologists. Here, we developed a machine learning pipeline to identify, quantitate and diagnose EoE patients' at the whole slide image level. We propose a platform that combines multi-label segmentation deep network decision support system with dynamics convolution that is able to process whole biopsy slide. Our network is able to segment both intact and not-intact eosinophils with a mean intersection over union (mIoU) of 0.93. This segmentation enables the local quantification of intact eosinophils with a mean absolute error of 0.611 eosinophils. We examined a cohort of 1066 whole slide images from 400 patients derived from multiple institutions. Using this set, our model achieved a global accuracy of 94.75%, sensitivity of 94.13%, and specificity of 95.25% in reporting EoE disease activity. Our work provides state-of-the-art performances on the largest EoE cohort to date, and successfully addresses two of the main challenges in EoE diagnostics and digital pathology, the need to detect several types of small features simultaneously, and the ability to analyze whole slides efficiently. Our results pave the way for an automated diagnosis of EoE and can be utilized for other conditions with similar challenges.
An inertial measurement unit (IMU) typically has three accelerometers and three gyroscopes. The output of those inertial sensors is used by an inertial navigation system to calculate the navigation solution–position, velocity and attitude. Since the sensor measurements contain noise, the navigation solution drifts over time. When considering low cost sensors, multiple IMUs can be used to improve the performance of a single unit. In this paper, we describe our designed 32 multi-IMU (MIMU) architecture and present experimental results using this system. To analyze the sensory data, a dedicated software tool, capable of addressing MIMUs inputs, was developed. Using the MIMU hardware and software tool we examined and evaluated the MIMUs for: (1) navigation solution accuracy (2) sensor outlier rejection (3) stationary calibration performance (4) coarse alignment accuracy and (5) the effect of different MIMUs locations in the architecture. Our experimental results show that 32 IMUs obtained better performance than a single IMU for all testcases examined. In addition, we show that performance was improved gradually as the number of IMUs was increased in the architecture.
An inertial navigation system is commonly used in various marine platforms above and below the sea surface to calculate the position, velocity and orientation of its carrier platform. Such systems contain an inertial measurement unit (IMU) to measure the specific force and angular velocity which in turn are integrated to obtain the navigation state. Due to sensor noises and other error terms, the navigation solution drifts in time. In situations of pure inertial navigation (no external aiding), multiple IMUs (MIMU) can be used to improve the performance of a single unit. In this paper, we explore the benefits of using a MIMU system for common navigation operations. To that end, a 32 MIMU architecture (192 inertial sensors) was designed and constructed for the experimental evaluations. Utilizing this system we examined the effect of the number of sensors in the architecture versus position accuracy, stationary calibration, coarse alignment and gyro free design. We derive closed form empirical expressions enabling insight to the connection between number of IMUs to the expected performance.INDEX TERMS Inertial measurement unit, multiple sensors, calibration, gyro-free, coarse alignment.
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