The search for new selective pharmacological agents with no significant side-effects is an increasing requirement for the development of new drugs to be used in the treatment of acute and chronic pain. In the present study, a new series of compounds (VAM 1,6,10,11, 12, 24) has been screening in QSARLDA mathematic models and pharmacologically evaluated. The antinociceptive properties of the new analgesic candidates obtained of virtual screening have been investigated in vitro tests. The pre-treatment with the compounds VAM 1, 2-4, 6, 10, 11, 12, showed a potent inhibition of IL-6 on RAW cells. The blocking efficacy of nineteen compounds on several isoforms of voltage-dependent sodium channels, expressed in Xenopus laevis oocytes, was tested (Nav1.3, Nav1.5, Nav1.6, Nav1.7, and Nav1.8). An exception was Nav1.6, where VAM 24 compound to result in substantial block indicating that acts specifically at this peculiar isoform. Compounds VAM 10 and VAM 2-4 are the most potent antinociceptive agents. These results indicate the potential of the compound VAM 2-4 to treat pain conditions.
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