Context
New biomarkers are needed in acetaminophen (APAP) hepatotoxicity. Plasma argininosuccinate synthetase (ASS) is a promising candidate.
Objective
Characterize ASS in APAP hepatotoxicity.
Methods
ASS was measured in plasma from rodents and humans with APAP hepatotoxicity.
Results
In mice, ASS increased before injury, peaked before ALT, and decreased rapidly. Fischer rats had a greater increase in ASS relative to ALT. Patients with abnormal liver test results had very high ASS compared to controls. ASS appeared to increase early in some patients, and declined rapidly in all.
Conclusions
: ASS may be a useful biomarker of acute cell death in APAP hepatotoxicity.
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