Human coronaviruses are highly contagious pathogens that cause acute respiratory syndrome in humans. Detailed characterization of the pathogen and appropriate detection techniques are critical for rapid clinical decision making in order to treat the infected individuals and also to prevent further spread of the disease. Recent pandemic caused by SARS-CoV2 that causes COVID-19 disease is an example that demonstrates the severity of such a crisis. Coronavirus genome consists of numerous accessory genes that contribute to the rapid adaptation and enhanced infectivity of the virus to a given host cell. Coronaviruses infect the human pulmonary system and cause widespread diffused alveolar damage, eventually causing hypoxia in the human body. Severe infection in immunocompromised individuals could lead to multiple organ failures and subsequent death.Application of popular imaging-based techniques such as CT for the diagnosis of coronavirus disease during a pandemic situation is limited as they are timeconsuming, costly, and nonportable in addition to lack of specific and reliable imaging markers. This chapter focuses on tackling these issues by taking two
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