OBJECTIVES: The purpose of the study was to determine the salivary composition of Oral squamous cell carcinoma patients. METHODOLOGY: A retrospective study was conducted over 6 months on data of 60 Oral squamous cell carcinoma patients obtained from the patient records of the Institute of Radiotherapy and Nuclear Medicine, Peshawar. Salivary pH, Sodium, Potassium, and total proteins of Oral squamous cell carcinoma patients were recorded. RESULTS: Sodium, Potassium, and total protein concentration in saliva of oral squamous cell carcinoma patients were 23.5 mM/L, 96.7mM/L, and 234.6 mM/L, respectively. These values were significantly higher than normal salivary concentration. CONCLUSION: It was concluded that the saliva of oral squamous cell carcinoma patients contains higher concentrations of Sodium, Potassium, and total proteins.
Background: Vitamin B12 is also known as cobalamin and is a hydrophilic vitamin, it is involved in metabolism of every cell of the body. It is a cofactor in DNA synthesis RNA, hormones, proteins, and lipids, and in both fatty acid and amino acid metabolism. Low levels of serum vitamin B12 may trigger pain in patients suffering from trigeminal neuralgia. Methylcobalamin, a form of Vitamin B12, protects against neurological diseases and aging. Mauro showed that high doses of methylcobalamin are needed to regenerate neurons as well as the myelin sheath that protects nerve axons and the peripheral nerves.Objective: The prime focus of this study was to report the frequency of low serum Vitamin B12 level in Identified Trigeminal Neuralgia patients visiting Peshawar Dental College and Hospital and to find the effect of gender on low serum vitamin B12 levels.Methods: A total of 90 known trigeminal neuralgia patients seeking treatment at the Department of Oral Medicine, Peshawar Dental College and Hospital were enrolled. All patients were advised to carry out serum Vitamin B12 level in laboratory. Data were analyzed by SPSS version 19. The statistical significance was set up at p <0.05.Results: Out of 90 known trigeminal neuralgia patients, 58.8% were females and 41.1% were males. 43.3% females and 27.0%males had low serum Vitamin B12 levels. No statistical significant difference between gender and low serum vitamin B12 level was found.Conclusions: Study confirms that gender has no effect on low serum levels of B12 in trigeminal neuralgia patients and a highproportion of trigeminal neuralgia patients had a low serum vitamin B12 levels.
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