The aim of the study is to analyze the literature available, to examine bariatric surgery as a treatment for people with metabolic syndrome (a risk factor for atypical endometrial hyperplasia), and to evaluate bariatric surgery significance in reducing endometrial cancer incidence.
Materials and Methods. The authors scanned the platforms Springer, Pubmed, IFSO, and Google Scholar using such key words as metabolic syndrome, simple and atypical endometrial hyperplasia, endometrial cancer and bariatric surgery, methods for the metabolic syndrome correction in patients with endometrial cancer, effects of bariatric surgery on endometrial cancer, treatment of metabolic syndrome in patients-at-risk for endometrial cancer. The authors examined the articles published in English and Russian no longer than 10 years ago.
Results. Metabolic syndrome is a risk factor for endometrial cancer and comorbidity. It expands the bariatric surgery alternatives for patients with Class 1 and Class 2 obesity.
Background: Optimal therapy for radically treated SCLC is concurrent hyperfractionated chemoradiotherapy (CCRT-45 Gy/30fractions/3 weeks, 3-D conformal) and prophylactic cranial irradiation (after complete or a good partial response). CCRT is not always feasible; patients may then have sequential chemoradiotherapy (SCRT)-45 Gy/15 fractions/3 weeks, 2D or 3D planned. Methods: CCRT and 3D planning were introduced locally in 2010. We reviewed all SCLC cases treated with both chemotherapy (CT) and radiotherapy (RT) with potentially curative intent between 2010 and 2014 at Velindre Cancer Centre. Results: 87 patients were treated. 86 received both CT and RT (73 sequential and 13 concurrent). One deteriorated after cycle 1 chemotherapy (further CT/RT cancelled). The median age was 66 (range 36-85). 51 were female, 36 were male. WHO PS at presentation: 0-36%, 1-43%, 2-18%, 3-2%. 70% had stage III disease. 44 patients had 2D RT planning; 42 patients had 3D; 3D planning increased over time. Only 15% received CCRT.
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