Our results suggest that patients can psychologically cope with cancer panel testing, but distress and uncertainty observed in carriers of moderate penetrance cancer variants in this cohort warrant further research.
Numerous cell models have been approached to study cancer biology. Some of those models are primary cell cultures, as well as, cancer cell lines derived from tumors. Several breast cancer cell lines are available for scientific research. Nevertheless, those cell lines do not represent all the cancer types and subtypes, neither their origin corresponds to most of the ethnic groups of the world. The main goal of this study is to generate and partially characterize cancer cell lines from tumor tissue obtained from Mexican patients with breast cancer, which can be used as models to study cancer biology and to characterize the phenotype and genotype of breast cancer affecting Mexican population. At present, four primary cell cultures (ID010, ID012, ID013 and ID014) have been established from primary tumor tissues representative of infiltrating ductal carcinomas, such as luminal B and HER‐enriched molecular subtypes. In addition, all the primary cell cultures showed the expression of cytokeratins, which suggests the presence of epithelial cells. The development and partial characterization of new breast cancer cell lines with different molecular subtypes, will allow us a better comprehension about the variations in morbidity, mortality and susceptibility to anti‐cancer drugs among different ethnicities.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.