The objective of this proof-of-concept study was to develop a platform for controlled drug delivery based on silk fibroin (SF) and to explore the feasibility of using SF in oral drug delivery. The SF-containing matrixes were prepared via spray-drying and film casting, and the release profile of the model drug naproxen sodium was evaluated. Attenuated total reflectance Fourier transform infrared spectroscopy (FTIR) has been used to observe conformational changes in SF- and drug-containing compositions. SF-based films, spray-dried microparticles, and matrixes loaded with naproxen were prepared. Both FTIR spectra and in vitro dissolution data demonstrated that SF β-sheet conformation regulates the release profile of naproxen. The controlled release characteristics of the SF-containing compositions were evaluated as a function of SF concentration, temperature, and exposure to dehydrating solvents. The results suggest that SF may be an attractive polymer for use in controlled drug delivery systems.
Degradation of cetirizine in polyethylene glycol arose from the reaction between the drug and the reactive peroxide intermediates such as peroxyl radicals formed through oxidation of PEG. Selective oxidation of cetirizine and isolation/characterization of the oxidation product allowed the identification of the oxidation product as cetirizine N-oxide. The mechanism of oxidation is proposed.
A rapid, sensitive, stability indicating, reversed phase HPLC method for the quantitation of Metoclopramide and its related compounds is described. injected on a reverse phase CIS column with a mobile phase of 0.15M ammonium acetate and acetonitrile (80:20) w i t h W detection at 268 nm. The method is highly specific, sensitive and has the ability to separate Metoclopramide narnely, 4-acetylamino-5-chloro-N[2(diethylamino)ethyll-2-methoxybenzamide hydrochloride and 4-amino-5-chloro-2methoxybenzoic acid in quantities of up to 10 ucg/mL. is highly reproducible with average assay recovery of 104.7 2 1.1%.The sample is extracted in methanol and from its related compunds;The method 1365 Copyright 0 1989 by Marcel Dekker, Inc. Drug Dev Ind Pharm Downloaded from informahealthcare.com by McMaster University on 11/03/14 For personal use only.
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