The dynamics of a cell is always changing. Cells move, divide, communicate, adapt, and are always reacting to their surroundings non-synchronously. Currently, single-cell metabolomics has become the leading field in understanding the phenotypical variations between them, but sample volumes, low analyte concentrations, and validating gentle sample techniques have proven great barriers toward achieving accurate and complete metabolomics profiling. Certainly, advanced technologies such as nanodevices and microfluidic arrays are making great progress, and analytical techniques, such as matrix-assisted laser desorption ionization (MALDI), are gaining popularity with high-throughput methodology. Nevertheless, live single-cell mass spectrometry (LCSMS) values the sample quality and precision, turning once theoretical speculation into present-day applications in a variety of fields, including those of medicine, pharmaceutical, and agricultural industries. While there is still room for much improvement, it is clear that the metabolomics field is progressing toward analysis and discoveries at the single-cell level.
Chemical analysis of glass from African archaeological sites has become a standard research tool over the past decades. Despite the multiplication of studies, the continent still exhibits vast unexplored regions. One of these is the surroundings of Lake Chad. This paper discusses the results of LA‐ICP‐MS analysis of recently excavated glass beads from the late medieval Chadian site of Tié. We demonstrate that the composition of those glass beads largely matches assemblages from along the East African coast. This indicates that most of the beads examined entered the region via a hitherto undocumented east–west Sudanic route linking Northeast Africa with Lake Chad.
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