Alzheimer's disease (AD) is a progressive neurodegenerative disorder primarily caused by accumulation of amyloid-beta (Aβ) peptide extracellularly and neurofibrillary tangles intracellularly. Recently, it has been shown that oxidative stress and mitochondrial dysregulation play an important role in pathology of AD. Therefore, modulating various targets such as Aβ aggregation, neuro-inflammation, and oxidative stress, genetic factors such as Apolipoprotein E gene (ApoE) are some of the ways to manage AD. Studying the natural products which can act as multifunctional agents could be key toward discovering new therapeutics. Ferulic acid (FA) represents one such natural product, which has exhibited great potential in this regard.Found in the plant cell walls, FA is an antioxidant, free radical scavenger with antiinflammatory activity. Taking this into consideration, over the years, various derivatives have been reported as anti-AD molecules based on structure of FA. The present review explores the role of FA and its derivatives as therapeutic agents in AD.
Surgical dental procedures cause pain and inflammation leading to temporary restriction of the movement of the oral cavity. Consumption of analgesic medications in the form of tablets or dispersible tablets causes compliance issues due to the compromised movability of the mandibular joint. An Orally Disintegrating Film (ODF), due to its pliability and compact size, can be a patient compliant tool for management of postoperative dental pain over parenterally administered opioids, conventional as well as orodispersible tablets of steroids or NSAIDS. Due to the inadequacies involved in solvent-casting, an unmet need exists for a continuous, eco-friendly and patient compliant process of manufacturing. The present research work addresses the unmet need of a patient compliant delivery system containing ketorolac tromethamine by Hot Melt Extrusion. The ODF optimized by Quality by Design was found to be stable with excellent mechanical properties and provided superior release profile as compared to the equivalent marketed formulation.
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