A facile and eco‐friendly visible light‐mediated synthesis of symmetrical and unsymmetrical disulfides using tris[2‐phenylpyridinato‐C2,N]iridium(III) under additive and oxidant free conditions has been disclosed. The developed method is very mild, several functional group tolerant and highly atom economical requiring extremely low amount of catalyst loading (0.5 mol%).magnified image
A Ru-catalyzed direct oxidative coupling reaction of vinyl ketones was developed. It offers a straightforward and atom-economical protocol for synthesis of functionalized (E,E)-1,6-dioxo-2,4-diene derivatives in moderate to good yields with...
A divergent formal synthesis of polyhydroxylated macrocyclic
lactone (+)-aspicillin and polyene bioactive natural product β-parinaric
acid and the total synthesis of non-terpenoid metabolite isolaurepan
have been achieved using a ruthenium-catalyzed stereo- and chemoselective
oxidative coupling reaction of easily accessible vinyl ketones and
acrylates. The crucial transformation involves the efficient synthesis
and functionalization of stereodefined (E,E)-1,6-dioxo-2,4-dienes
using simple reaction protocols, which enabled straightforward access
to a diverse range of bioactive natural products.
A bioinspired, catalytic approach to the enantioselective total syntheses of antibacterial callistrilones A, C-E and 13-epi-callistrilone E natural products containing unprecedented, sterically compact [1]benzofuro-[2,3-a]xanthene 6/6/6/5/6/3-fused hexacyclic skeleton is described. The...
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