Background Chemotherapeutic resistance is the main cause of clinical treatment failure and poor prognosis in triple-negative breast cancer (TNBC). There is no research on chemotherapeutic resistance in TNBC from the perspective of circular RNAs (circRNAs). Methods TNBC-related circRNAs were identified based on the GSE101124 dataset. Quantitative reverse transcription PCR was used to detect the expression level of circWAC in TNBC cells and tissues. Then, in vitro and in vivo functional experiments were performed to evaluate the effects of circWAC in TNBC. Results CircWAC was highly expressed in TNBC and was associated with worse TNBC patient prognosis. Subsequently, it was verified that downregulation of circWAC can increase the sensitivity of TNBC cells to paclitaxel (PTX) in vitro and in vivo. The expression of miR-142 was negatively correlated with circWAC in TNBC. The interaction between circWAC and miR-142 in TNBC cells was confirmed by RNA immunoprecipitation assays, luciferase reporter assays, pulldown assays, and fluorescence in situ hybridization. Mechanistically, circWAC acted as a miR-142 sponge to relieve the repressive effect of miR-142 on its target WWP1. In addition, the overall survival of TNBC patients with high expression of miR-142 was significantly better than that of patients with low expression of miR-142, and these results were verified in public databases. MiR-142 regulated the expression of WWP1 and the activity of the PI3K/AKT pathway. It was confirmed that WWP1 is highly expressed in TNBC and that the prognosis of patients with high WWP1 expression is poor. Conclusions CircWAC/miR-142/WWP1 form a competing endogenous RNA (ceRNA) network to regulate PI3K/AKT signaling activity in TNBC cells and affect the chemosensitivity of cells.

light absorption and charge separation efficiency is a key step to boost the PEC performance. In the past decades, metal oxides such as TiO 2 , [5,6] Fe 2 O 3 , [7][8][9] and BiVO 4 [10][11][12] have been widely investigated as photoanodes for PEC water splitting due to the characteristics of excellent photoactivity, low cost, and good stability. Among them, BiVO 4 semiconductor is particularly attractive because it has a narrow band gap of ≈2.4 eV, suitable conduction band (0 V vs reversible hydrogen electrode, RHE) and valence band edges, high water splitting efficiency, and good chemical stability. [13][14][15][16][17][18] Nevertheless, the poor charge transport ability, short carrier diffusion lengths (≈70 nm), and high charge recombination rates of BiVO 4 greatly limit its practical PEC performance. To address these problems, various strategies such as morphology design, element doping, host-guest heterojunctions and surface modifications are developed to enhance the performance. [19][20][21][22][23][24] Nanostructured electrode design is one effective route to enhance the light absorption and charge transport ability. For instance, 1D nanorods, [25] 2D nanosheets, [26] 3D inverse opals, [27] 3D hierarchical structures, [28][29][30] and 3D brochosomes-like arrays [31] have been reported to enhance the light harvesting and charge transport performance. Besides, the host-guest heterojunction electrode using two or more dissimilar materials to take the task of charge transport and light absorption, respectively, is another popular strategy to promote the charge transport and suppress the recombination of electron-hole pairs. [32] For instance, BiVO 4 as a light absorber has been combined with various other semiconductors to form a type II configuration such as TiO 2 /BiVO 4 , [33][34][35][36][37][38] WO 3 /BiVO 4 , [39][40][41][42] SnO 2 /BiVO 4 , [43,44] and Fe 2 O 3 /BiVO 4 . [45] Among them, TiO 2 is very attractive due to its relatively negative flat band potential and good chemical stability. Nevertheless, the intrinsically low mobility of TiO 2 still greatly limits the overall performance of TiO 2 /BiVO 4 heterojunction photoanode.Herein, we report the rational design and fabrication of 3D hierarchical ternary SnO 2 /TiO 2 /BiVO 4 arrays as photoanode for photoelectrochemical water splitting by combining multiple routes of colloid microspheres template, hydrothermal, atomic layer deposition (ALD), and electrodeposition. In this electrode design, the hierarchically hollow SnO 2 microspheres@ nanosheets arrays act as skeletons to support the TiO 2 and BiVO 4 as a promising semiconductor absorber is widely investigated as photoanode in photoelectrochemical water splitting. Herein, the rational design of 3D hierarchical ternary SnO 2 /TiO 2 /BiVO 4 arrays is reported as photoanode for photoelectrochemical application, in which the SnO 2 hierarchically hollow microspheres core/nanosheets shell arrays act as conductive skeletons, while the sandwiched TiO 2 and surface BiVO 4 are working as hole blocking layer a...

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The exploration on efficient self-powered solar-blind photodetectors is essential for future sustainable optoelectronic system under tremendous application scenarios. Herein, we demonstrate a photoelectrochemical (PEC)-type heterojunction-driven solar-blind detector constructed by atomic...

Developing highly active, cost‐effective, and durable bifunctional oxygen electrocatalysts is an important step for the advancement of rechargeable Zn–air batteries (ZABs). Herein, an efficient bifunctional oxygen electrocatalyst of ultrathin Co(OH)2 nanosheets supported on nitrogen‐doped carbon nanoflake arrays (named as Co(OH)2@NC), is reported, which yields excellent bifunctional activity, i.e., a low overpotential of 285 mV to reach 10 mA cm−2 for oxygen evolution reaction (OER), a high half‐wave potential (0.83 V) for oxygen reduction reaction (ORR), and a low potential gap (ΔE) of 0.69 V. The excellent bifunctional catalytic performance can be ascribed to the concerted efforts of cobalt hydroxide toward OER and nitrogen‐doped carbon for ORR. The Co(OH)2@NC nanoflake arrays is further used as binder‐free air cathodes for rechargeable Zn–air batteries, exhibiting a high specific capacity of 798.3 mAh gZn−1, improved stability (a working life of >70 h at 5 mA cm−2), as well as a reduced long‐term charging voltage, which outperforms the counterparts of NC nanoflake arrays and Pt/C‐based air cathodes. One step further, the Co(OH)2@NC nanoflake arrays on carbon cloth are directly used as binder‐free air cathodes for flexible, solid‐state ZABs, showing excellent performance under deformation as well.