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Pruritus, also known as itch, is classically defined as an uncomfortable sensation that provokes a desire to scratch. 1 Mild temporal pruritus is non-pathological and physiologically functional to remove external elements from one's own body. On the other hand, severe chronic pruritus is pathological and significantly affects quality of life. 2 Moreover, recurring pruritus leads to repeated scratching (itch-scratch cycle), aggravating disease morbidity by further damaging the skin and increasing proinflammatory cytokine release. 3 Therefore, the treatment of pruritus is important not only for relief from the uncomfortable sensation itself, but also for stopping the itch-scratch cycle, preventing disease exacerbation.Pemphigoid diseases (PDs) are a group of disorders characterized by tense blisters and edematous erythema, which include multiple diseases associated with severe pruritus, such as bullous pemphigoid (BP), epidermolysis bullosa acquisita (EBA), pemphigoid gestationis (PG), and linear IgA dermatosis (LAD). 4 Treatment targeting pruritus in PDs is important since itch in PDs is often intractable and significantly impairs patients' quality of life (QOL), with scratch behaviors

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