Brain image segmentation is one of the most time-consuming and challenging procedures in a clinical environment. Recently, a drastic increase in the number of brain disorders has been noted. This has indirectly led to an increased demand for automated brain segmentation solutions to assist medical experts in early diagnosis and treatment interventions. This paper aims to present a critical review of the recent trend in segmentation and classification methods for brain magnetic resonance images. Various segmentation methods ranging from simple intensity-based to high-level segmentation approaches such as machine learning, metaheuristic, deep learning, and hybridization are included in the present review. Common issues, advantages, and disadvantages of brain image segmentation methods are also discussed to provide a better understanding of the strengths and limitations of existing methods. From this review, it is found that deep learning-based and hybrid-based metaheuristic approaches are more efficient for the reliable segmentation of brain tumors. However, these methods fall behind in terms of computation and memory complexity.

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Intensity inhomogeneity, hidden details, poor image contrast due to low capturing device quality, limited user experience, and inappropriate environment setting during data acquisition are major issues reported during the image enhancement process. Histogram Equalization (HE) approaches have been commonly deployed to overcome the above-listed problems, apart from improving image contrast. Nevertheless, the resulting images retrieved after undergoing these approaches are often affected by undesired artifacts, unnatural looks, and unpleasant washed-out effects. As such, this study introduces a new approach called Adaptive Clip Limit Tile Size Histogram Equalization (ACLTSHE). The ACLTSHE initially assigns the optimum clip limit (CL) and tile size minimum or maximum values. Then, a new fitness function called DataSignal is deployed to produce a set of non-dominated solutions by adaptively computing the optimum CL value. The performance of the proposed ACLTSHE approach was assessed and compared with conventional Clip Limit HE (CLHE) and several state-of-the-art approaches, such as Dynamic Clipped HE (DCLHE), Iterated Adaptive Entropy Clip Limit HE (IAECHE), Mean and Variance Sub-image HE (MVSIHE), and Adaptive Entropy Index HE (AEIHE). The outcomes were assessed both qualitatively and quantitatively by using six evaluation metrics, Discrete Entropy (DE), Absolute Mean Brightness Error (AMBE), Peak Signalto-Noise Ratio (PSNR), Contrast Improvement Index (CII), Root Mean Square Error (RMSE), Structure Similarity Index (SSI) and Standard Deviation (SD). The quantitative evaluation of three dataset images (Pasadena-houses 2000, faces 1999, and BraTS 2019) verified that the proposed approach outperformed the compared approaches in terms of improved DE, enhanced contrast, and highlighted local details without losing the original image structures. INDEX TERMS Histogram equalization-based technique, histogram entropy, histogram clip limit, tile size.

This article provides a comprehensive review of deep learning-based blood vessel segmentation of brain. The cerebrovascular disease develops when blood arteries in the brain are compromised, resulting in severe brain injuries such as ischemic stroke, brain hemorrhages, and many more. Early detection enables patients to obtain more effective treatment before becoming critically unwell. Due to the superior efficiency and accuracy compared to manual segmentation and other computer-assisted diagnosis procedures, deep learning algorithms have been extensively deployed in brain vascular segmentation. This study examined current articles on deep learning-based brain vascular segmentation, which examined the proposed methodologies, particularly the network architectures, and determined the model trend. We evaluated challenges and crucial factors associated with the application of deep learning to brain vascular segmentation, as well as future research prospects. This paper will assist researchers in developing more sophisticated and robust models in future to develop deep learning solution.